34653-56-0

Usage

Uses

Used in Pharmaceutical Industry:
5-(1,3-Benzothiazol-2-yl)-2-furaldehyde is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its potential antioxidant, anticancer, and antimicrobial activities make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
5-(1,3-Benzothiazol-2-yl)-2-furaldehyde is used as a key intermediate in the synthesis of various organic compounds, contributing to the development of new chemical entities with potential applications in various industries.
Used in Analytical Biochemistry:
5-(1,3-Benzothiazol-2-yl)-2-furaldehyde is used as a fluorescent probe in analytical biochemistry. Its fluorescent properties allow for the detection and analysis of biomolecules, providing valuable insights into biological processes and mechanisms.
Used in Cancer Diagnostics and Treatment:
5-(1,3-Benzothiazol-2-yl)-2-furaldehyde is used as a fluorescent probe in cancer diagnostics and treatment. Its high bioactivity and ability to bind to specific biomolecules make it a valuable tool for detecting and monitoring cancer cells, as well as for developing targeted therapies.

InChI:InChI=1/C12H7NO2S/c14-7-8-5-6-10(15-8)12-13-9-3-1-2-4-11(9)16-12/h1-7H

Upstream product

• 1569-98-8 2-(furan-2-yl)-1,3-benzothiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 137-07-5 2-amino-benzenethiol 
• 98-01-1 furfural 
• 95-16-9 1,3-Benzothiazole 
• 100-97-0 hexamethylenetetramine 
• 10243-03-5 furan-2-carbothioic acid anilide 
• 1929-89-1 furan-2-carboxylic acid phenylamide 
• 527-69-5 2-furancarbonyl chloride 

Downstream Products

• 1088704-67-9 (E)-2-{5-[2-(4-dimethylaminophenyl)-vinyl]-furan-2-yl}-benzothiazole 

Relevant academic research and scientific papers

Halo-Bridged Abnormal NHC Palladium(II) Dimer for Catalytic Dehydrogenative Cross-Coupling Reactions of Heteroarenes

This work describes the dehydrogenative coupling of heteroarenes using a dimeric halo-bridged palladium(II) catalyst bearing an abnormal NHC (aNHC) backbone. The catalyst can successfully activate the C-H bond of a wide range of heteroarenes, which include benzothiazole, benzoxazole, thiophene, furan, and N-methylbenzimidazole. Further, it exhibited good activity for heteroarenes bearing various functional groups such as CN, CHO, Me, OMe, OAc, and Cl. Additionally, we isolated the active catalyst by performing stoichiometric reaction and characterized it as the acetato-bridged dimer of (aNHC)PdOAc by single-crystal X-ray study.

Palladium-catalyzed oxidative C-H/C-H cross-coupling of benzothiazoles with thiophenes and thiazoles

A concise palladium-catalyzed method for oxidative C-H/C-H cross-coupling between benzothiazoles and thiophenes/thiazoles has been developed. This CDC reaction is insensitive to air and moisture with high functional group tolerance.

Synthesis and properties of 2-(2-furyl)benzothiazole

The electrophilic reactions (nitration, bromination, hydroxymethylation, formylation, acylation) and radical substitution reactions (nitration, arylation) of 2-(2-furyl)benzothiazole have been studied. It was found that all of the reactions occur at position 5 of the furan ring. Only nitration in PPA gave the 5′,6-dinitro derivative. Quantum-chemical calculation data for the electron density distribution in the neutral and protonated 2-(2-furyl)benzothiazole molecules are given.

Donor-π-acceptor benzothiazole-derived dyes with an extended heteroaryl-containing conjugated system: synthesis, DFT study and antimicrobial activity

A series of novel derivatives containing an electron-donating N,N-dimethylaminophenyl ring connected to an electron-withdrawing benzothiazole or benzothiazolium moiety via a heteroaryl system (furan, thiophene or N-methylpyrrole) and up to two ethenylene

Candida antarctica lipase A in the dynamic resolution of novel furylbenzotiazol-based cyanohydrin acetates

A series of novel (R)-furylbenzotiazol-based cyanohydrin acetates were prepared in over 90% isolated yields from the corresponding furancarbaldehydes. The one-pot method combines a basic resin to produce hydrogen cyanide from acetone cyanohydrin, an equil