346579-32-6Relevant academic research and scientific papers
MLKL INHIBITORS
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Paragraph 0257-0258, (2018/09/26)
Purine derivatives that inhibit cellular necroptosis and/or human MLKL, pharmaceutical compositions thereof, and methods of treating an MLKL-mediated disorder with an effective amount of the compound or composition. Said MLKL-mediated disorder is pathology associated necroptosis, including ischemia-reperfusion damage, neurodegeneration, and inflammatory diseases such as acute pancreatitis, multiple sclerosis, inflammatory bowel disease, and allergic colitis.
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase
Booysen, Hermanus P.,Moraal, Christina,Terre'Blanche, Gisella,Petzer, Anél,Bergh, Jacobus J.,Petzer, Jacobus P.
experimental part, p. 7507 - 7518 (2012/01/03)
In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for enhancing the MAO inhibition potency
