346583-88-8Relevant academic research and scientific papers
Discovery of a novel lead structure for anti-malarials
Wiesner, Jochen,Wi?ner, Pia,Dahse, Hans-Martin,Jomaa, Hassan,Schlitzer, Martin
, p. 785 - 792 (2001)
From a library of 61 compounds available from former studies, 2,5-bis-acylaminobenzophenone 1 was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials. Copyright
Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors
Sakowski,B?hm,Sattler,Dahse,Schlitzer
, p. 2886 - 2899 (2007/10/03)
Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure - activity relationship of a nove
