41019-22-1

Upstream product

• 41018-87-5 2-methyl-3-phenyl-5-nitroindole 
• 108-24-7 acetic anhydride 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 75-36-5 acetyl chloride 
• 70063-29-5 benzyl methyl ketone p-nitrophenylhydrazone 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1775-95-7 2-amino-5-nitrobenzophenone 
• 64-19-7 acetic acid 
• 76303-80-5 2-Benzoyl-4-nitrophenyl-bis<6-nitro-4-phenylchinolyl-(2)>amin 
• 346583-88-8 N-(4-amino-2-benzoylphenyl)acetamide 
• 366456-51-1 N-[4-(acetylamino)-3-benzoylphenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 

Relevant academic research and scientific papers

Quinolinone compounds serving as selective phosphodiesterase 2 inhibitors and preparation method of quinolinone compounds

The invention belongs to the field of chemical medicines, and particularly relates to quinolinone compounds serving as selective phosphodiesterase 2 inhibitors and a preparation method of the quinolinone compounds. The invention provides the quinolinone compounds, the general formula of the quinolinone compounds is represented by a formula (A), and the quinolinone compounds have a high-intensity inhibition effect on PDE2 and have high selectivity on other PDE subtypes. The invention also provides a preparation method of the derivatives, and the preparation method is scientific, reasonable, simple and feasible. The quinolinone compounds disclosed by the invention are used for preparing medicines for treating memory and cognitive impairment, neurodegenerative diseases and cardiovascular diseases.

Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors

Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure - activity relationship of a nove

Discovery of a novel lead structure for anti-malarials

From a library of 61 compounds available from former studies, 2,5-bis-acylaminobenzophenone 1 was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials. Copyright

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.