346592-33-4Relevant academic research and scientific papers
Indole derivatives for the treatment of depression and anxiety
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Page/Page column 57, (2010/02/05)
The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1
Takeuchi, Kumiko,Kohn, Todd J.,Honigschmidt, Nicholas A.,Rocco, Vincent P.,Spinazze, Patrick G.,Koch, Daniel J.,Nelson, David L.,Wainscott, D. Bradley,Ahmad, Laura J.,Shaw, Janice,Threlkeld, Penny G.,Wong, David T.
, p. 1903 - 1905 (2007/10/03)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT1A receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities.
