346592-34-5Relevant academic research and scientific papers
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1
Takeuchi, Kumiko,Kohn, Todd J.,Honigschmidt, Nicholas A.,Rocco, Vincent P.,Spinazze, Patrick G.,Koch, Daniel J.,Nelson, David L.,Wainscott, D. Bradley,Ahmad, Laura J.,Shaw, Janice,Threlkeld, Penny G.,Wong, David T.
, p. 1903 - 1905 (2007/10/03)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT1A receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities.
