346592-35-6Relevant academic research and scientific papers
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2
Takeuchi, Kumiko,Kohn, Todd J.,Honigschmidt, Nicholas A.,Rocco, Vincent P.,Spinazze, Patrick G.,Koch, Daniel J.,Atkinson, Steven T.,Hertel, Larry W.,Nelson, David L.,Wainscott, D. Bradley,Ahmad, Laura J.,Shaw, Janice,Threlkeld, Penny G.,Wong, David T.
, p. 2393 - 2397 (2003)
Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an α-Me group in the piperidine ring with its specific stereochemistry enhanced binding affinity at the 5-HT reuptake site and in vitro 5-HT1A antagonist functional activity.
