34662-35-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-nitrobenzonitrile is used as an intermediate in the synthesis of various pharmaceuticals. Its unique reactivity and properties make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
2-Bromo-4-nitrobenzonitrile is also used as an intermediate in the production of agrochemicals. Its role in the synthesis of these compounds contributes to the development of effective agricultural products.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-Bromo-4-nitrobenzonitrile is utilized for the creation of a wide range of chemical compounds. Its presence of bromine and nitro groups allows for versatile reactions and the formation of diverse products in the field of organic chemistry.

Upstream product

• 89001-53-6 2-cyano-5-nitrotoluene 
• 13296-94-1 2-bromo-4-nitroaniline 
• 544-92-3 copper(I) cyanide 
• 151-50-8 potassium cyanide 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 53312-82-6 4-amino-2-bromobenzonitrile 
• 1219037-01-0 7-nitro-2-propyl-4-aminoquinazoline 
• 1006899-23-5 4-amino-2-cyclopropylbenzonitrile 
• 92163-95-6 2-(benzylsulfanyl)-4-nitrobenzoic acid 

Relevant academic research and scientific papers

BIARYLMETHYL HETEROCYCLES

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Palladium-catalyzed highly selective ortho-halogenation (I, Br, Cl) of arylnitriles via sp2 C-H bond activation using cyano as directing group

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature. Using cyano as the directing group, the halogenation reaction gave good to excellent yields. The method is compatible to the arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available to the substrate in at least gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.

Concise synthesis of highly substituted benzo[a]quinolizines by a multicomponent reaction/allylation/heck reaction sequence

The combination of the recently developed multicomponent construction of highly substituted 3,4-dihydropyridones with subsequent allylation and intramolecular Heck-type cyclization allows the straightforward construction of benzo[a]quinolizines, a class of polycyclic compounds that- despite their interesting pharmacological and photochemical properties- have little precedent in the literature. After optimization of the individual steps, we used this reliable three-step sequence to generate a small library of diversely substituted benzo[a]quinolizines and various heterocyclic analogs. Copyright

FUSED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION

Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.

ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Isoquinoline Derivatives, compositions comprising an effective amount of a Isoquinoline Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease other than a cardiovascular disease, cardiovascular disease, reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Isoquinoline Derivative.