34662-35-6Relevant articles and documents
BIARYLMETHYL HETEROCYCLES
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Page/Page column 94-95, (2018/02/28)
The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.
Concise synthesis of highly substituted benzo[a]quinolizines by a multicomponent reaction/allylation/heck reaction sequence
Den Heeten, Rene,Van Der Boon, Leon J. P.,Broere, Daniel L. J.,Janssen, Elwin,De Kanter, Frans J. J.,Ruijter, Eelco,Orru, Romano V. A.
supporting information; experimental part, p. 275 - 280 (2012/02/04)
The combination of the recently developed multicomponent construction of highly substituted 3,4-dihydropyridones with subsequent allylation and intramolecular Heck-type cyclization allows the straightforward construction of benzo[a]quinolizines, a class of polycyclic compounds that- despite their interesting pharmacological and photochemical properties- have little precedent in the literature. After optimization of the individual steps, we used this reliable three-step sequence to generate a small library of diversely substituted benzo[a]quinolizines and various heterocyclic analogs. Copyright
ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF
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Page/Page column 94-95, (2008/06/13)
The present invention relates to Isoquinoline Derivatives, compositions comprising an effective amount of a Isoquinoline Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease other than a cardiovascular disease, cardiovascular disease, reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Isoquinoline Derivative.