346694-31-3

Upstream product

• 116278-62-7 25-O-methylmonensin methyl ester 
• 244088-32-2 25-O-methyl-26-O-t-butyldimethylsilylmonensin methyl ester 
• 35424-56-7 1-chloro-4-(iodomethyl)benzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 346694-27-7 6-{5'-[9-(4-chloro-benzyloxy)-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid 
• 346694-46-0 7-O-p-chlorobenzyl-25-O-methyl-25-carboxymonensin 
• 346694-38-0 7-O-p-chlorobenzyl-25-O-methyl-25-formylmonensin methyl ester 
• 346694-28-8 4-{9-(4-chloro-benzyloxy)-2-[2-ethyl-5'-(6-hydroxymethyl-6-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-3'-methyl-octahydro-[2,2']bifuranyl-5-yl]-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-7-yl}-3-methoxy-2-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity

Monensin (1), an ionophore antibiotic agent, was converted to 25-carboxymonensin (2) and 7-O-substituted-25-carboxyl derivatives (3a-d), which have two carboxyl groups at both ends of the molecule. Ca2+ ion transport activity of the dicarboxylic monensins was evaluated by the CHCl3 liquid membrane method, and 25-carboxymonensins (2 and 3a-d) were shown to transport the Ca2+ ion through the CHCl3 liquid membrane.