346698-53-1Relevant academic research and scientific papers
Palladium-Catalyzed α-Arylation of Methyl Sulfonamides with Aryl Chlorides
Zheng, Bing,Li, Minyan,Gao, Gui,He, Yuying,Walsh, Patrick J.
supporting information, p. 2156 - 2162 (2016/07/16)
A palladium-catalyzed α-arylation of sulfonamides with aryl chlorides is presented. A Buchwald-type pre-catalyst formed with Kwong’s indole-based ligand enabled this transformation to be compatible with a large variety of methyl sulfonamides and aryl chlorides in good to excellent yields. Importantly, under the optimized reaction conditions, only mono-arylated products were observed. This method has been applied to the efficient synthesis of sumatriptan, which is used to treat migraines. (Figure presented.) .
A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives
Zhou, Gang,Ting, Pauline,Aslanian, Robert,Piwinski, John J.
supporting information; experimental part, p. 2517 - 2520 (2009/05/26)
(Chemical Equation Presented) A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed α-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.
