3467-13-8

Upstream product

• 35458-21-0 phlorisobutyrophenone 
• 74-88-4 methyl iodide 

Downstream Products

• 54247-23-3 6,8-dihydroxy-5-isobutyryl-9-isopropyl-2,2,4,4-tetramethyl-2H-xanthene-1,3(4H,9H)-dione 
• 61565-12-6 2,2,4,4-tetramethyl-6-(2-methylpropylidene)-cyclohexane-1,3,5-trione 

Relevant academic research and scientific papers

Biomimetic synthesis of myrtucommulone K, N and O

A concise total synthesis of myrtucommulone K, N and O have been developed in 4 steps from commercially available materials. The synthetic strategy was inspired primarily by the biogenetic hypothesis and firstly enabled via a reduction, dehydration sequen

Biomimetic Syntheses of Callistrilones A-E via an Oxidative [3 + 2] Cycloaddition

Concise total syntheses of callistrilones A-E have been achieved from 7 and commercially available α-phellandrene (8). The synthetic strategy, which was primarily inspired by the biogenetic hypothesis, was enabled by an oxidative [3 + 2] cycloaddition fol

Preparation method of antimicrobial agent

The invention relates to a preparation method of an antibacterial agent. The preparation method of the antibacterial agent comprises the steps of selecting sodium methoxide, a compound A with the structure formula which is shown in the description and iodomethane as starting materials, then performing methylation, reduction, a Michael reaction, reduction, tandem ring-increasing reactions of Michael ketalization tandem annelationketal and the Michael reaction to obtain the antimicrobial agent with the structure formula which is shown in the description. That is, the antimicrobial agent is prepared by chemical synthesis can, increase increasing the sources of antimicrobial agents, which is conducive to wider application.

Preparation method of antimicrobial agent

The invention relates to a preparation method of an antibacterial agent. The preparation method of the antibacterial agent comprises selecting sodium methoxide, a compound A and iodomethane as starting materials, then performing reduction, a Michael reaction, a dehydration ring-closing reaction, oxidation and a hydrolysis ring-opening reaction to obtain the antimicrobial agent with the structure formula which is shown in the description. That is, the antimicrobial agent is prepared by chemical synthesis can, increase increasing the sources of antimicrobial agents, which is conducive to wider application.

Preparation method of antimicrobial agent

The invention relates to a preparation method of an antibacterial agent. The preparation method of the antibacterial agent comprises selecting sodium methoxide, a compound A with the structure formulawhich is shown in the description and iodomethane as starting materials, then performing reduction, a ring-closing reaction, oxidation and a ring-opening reaction and the like to obtain the antimicrobial agent with the structure formula which is shown in the description. That is, the antimicrobial agent is prepared by chemical synthesis, can increasinge the sources of antimicrobial agents, whichis conducive to wider application.

Synthesis and P-glycoprotein induction activity of colupulone analogs

Brain amyloid-beta (Aβ) plaques are one of the primary hallmarks associated with Alzheimer's disease (AD) pathology. Efflux pump proteins located at the blood-brain barrier (BBB) have been reported to play an important role in the clearance of brain Aβ, among which the P-glycoprotein (P-gp) efflux transporter pump has been shown to play a crucial role. Thus, P-gp has been considered as a potential therapeutic target for treatment of AD. Colupulone, a prenylated phloroglucinol isolated from Humulus lupulus, is known to activate pregnane-X-receptor (PXR), which is a nuclear receptor controlling P-gp expression. In the present work, we aimed to synthesize and identify analogs of colupulone that are potent P-gp inducer(s) with an ability to enhance Aβ transport across the BBB. A series of colupulone analogs were synthesized by modifications at both prenyl as well as acyl domains. All compounds were screened for P-gp induction activity using a rhodamine 123 based efflux assay in the P-gp overexpressing human adenocarcinoma LS-180 cells, wherein all compounds showed significant P-gp induction activity at 5 μM. In the western blot studies in LS-180 cells, compounds 3k and 5f were able to induce P-gp as well as LRP1 at 1 μM. The effect of compounds on the Aβ uptake and transport was then evaluated. Among all tested compounds, diprenylated acyl phloroglucinol 5f displayed a significant increase (29%) in Aβ transport across bEnd3 cells grown on inserts as a BBB model. The results presented here suggest the potential of this scaffold to enhance clearance of brain Aβ across the BBB and thus its promise for development as a potential anti-Alzheimer agent.

β-triketones from Myrtaceae: Isoleptospermone from Leptospermum scoparium and papuanone from Corymbia dallachiana

Naturally occurring β-triketones, isoleptospermone [3, 5-hydroxy-4-(2- methyl-1-oxopentyl)-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione) from Leptospermum scoparium] and papuanone [6, 5-hydroxy-4-(1-oxohexyl)-2,2,6,6- tetramethyl-4-cyclohexene-1,3-dione fr