61565-12-6

Upstream product

• 22595-45-5 6-isobutyryl-2,2,4,4-tetramethylcyclohexane-1,3,5-trione 
• 7181-79-5 syncarpic acid 
• 78-84-2 isobutyraldehyde 
• 3467-13-8 5-hydroxy-4-(isobutyryl)-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione 
• 7073-22-5 4-acetyl-5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione 
• 77744-52-6 5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione 
• 114751-25-6 2,2,4,4-Tetramethyl-6-(2-methyl-1-pyrrolidin-1-yl-propyl)-cyclohexane-1,3,5-trione 
• 83814-56-6 3-hydroxy-2-(2-methyl-1-piperidino)propyl-4,4,6,6-tetramethylcyclohex-2-ene-1,5-dione 

Downstream Products

• 54247-21-1 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methyl-1-(2,4,6-trihydroxy-3-(1-(2-hydroxy-3,3,5,5-tetramethyl-4,6-dioxocyclohex-1-enyl)-2-methylpropyl)-5-isobutyrylphenyl)propyl)cyclohex-4-ene-1,3-dione 
• 1225039-20-2 myrtucommulone A 

Relevant academic research and scientific papers

Bicyclic peroxides in the G factors series: Synthesis and electrochemical studies

Endoperoxides belonging to the family of G factors have been synthesised under Mannich type conditions. The structure of different diastereoisomers has been established on the basis of NMR experiments. Their cathodic peak potentials have been determined by thin-layer electrochemistry under potentiostatic conditions, and compared to that of artemisinin.

One-Pot Knoevenagel and [4 + 2] Cycloaddition as a Platform for Calliviminones

Bioactive compounds featuring an unusual core of spiro[5.5]undecenes and calliviminones were synthesized in very good yield with good regio- and diastereoselectivities through a one-pot Knoevenagel and [4 + 2] cycloaddition from the readily available aldehydes, cyclic-1,3-diones, dienes, and a catalytic amount of (s)-proline.

Catalytic asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B, and callistrilones A, C, D and e

Herein, we describe a concise catalytic approach to the first asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B, and callistrilones A, C, D and E. The syntheses proceed in only 5-7 steps from the readily available compound 11, witho

Biomimetic Total Syntheses of Callistrilones A, B, and D

A biomimetic total syntheses of antibacterial natural products (±)-callistrilones A, B, and D, the first triketone-phloroglucinol-monoterpene hybrids with an unprecedented [1]benzofuro[2,3-a]xanthene and [1]benzofuro[3,2-b]xanthene pentacyclic ring system

Preparation method of antimicrobial agent

The invention relates to a preparation method of an antibacterial agent. The preparation method of the antibacterial agent comprises the steps of selecting sodium methoxide, a compound A with the structure formula which is shown in the description and iodomethane as starting materials, then performing methylation, reduction, a Michael reaction, reduction, tandem ring-increasing reactions of Michael ketalization tandem annelationketal and the Michael reaction to obtain the antimicrobial agent with the structure formula which is shown in the description. That is, the antimicrobial agent is prepared by chemical synthesis can, increase increasing the sources of antimicrobial agents, which is conducive to wider application.

Preparation method of antimicrobial agent

The invention relates to a preparation method of an antibacterial agent. The preparation method of the antibacterial agent comprises selecting sodium methoxide, a compound A and iodomethane as starting materials, then performing reduction, a Michael reaction, a dehydration ring-closing reaction, oxidation and a hydrolysis ring-opening reaction to obtain the antimicrobial agent with the structure formula which is shown in the description. That is, the antimicrobial agent is prepared by chemical synthesis can, increase increasing the sources of antimicrobial agents, which is conducive to wider application.

Preparation method of antimicrobial agent

The invention relates to a preparation method of an antibacterial agent. The preparation method of the antibacterial agent comprises selecting sodium methoxide, a compound A with the structure formulawhich is shown in the description and iodomethane as starting materials, then performing reduction, a ring-closing reaction, oxidation and a ring-opening reaction and the like to obtain the antimicrobial agent with the structure formula which is shown in the description. That is, the antimicrobial agent is prepared by chemical synthesis, can increasinge the sources of antimicrobial agents, whichis conducive to wider application.

Biomimetic Syntheses of Callistrilones A-E via an Oxidative [3 + 2] Cycloaddition

Concise total syntheses of callistrilones A-E have been achieved from 7 and commercially available α-phellandrene (8). The synthetic strategy, which was primarily inspired by the biogenetic hypothesis, was enabled by an oxidative [3 + 2] cycloaddition fol

Metal catalysed versus organocatalysed stereoselective synthesis: The concrete case of myrtucommulones

Myrtucommulones belong to a class of pharmacologically active natural compounds which offer various alternatives to the treatment of pain, inflammation and cancer. Their stereoselective synthesis remains therefore a key-challenge towards its use in the pharmaceutical industry. In the present work myrtucommulone A and B were synthesised through metal catalysis with 81 and 72% ee respectively. Thanks to the use of cinchonidine as an organocatalyst, 82 and 84% de were reached for myrtucommulone A and myrtucommulone F respectively. Simultaneously, a new synthetic method emerged and gave access to new range of possibilities for the preparation of myrtucommulone derivatives under mild conditions or through a one-pot reaction.

Biomimetic synthesis of myrtucommulone K, N and O

A concise total synthesis of myrtucommulone K, N and O have been developed in 4 steps from commercially available materials. The synthetic strategy was inspired primarily by the biogenetic hypothesis and firstly enabled via a reduction, dehydration sequen