346708-19-8

Upstream product

• 346708-20-1 (2R,3R/S)-1-(p-methoxybenzyloxy)-2-methylpentane-3,5-diol 
• 160238-46-0 (2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal 
• 346708-21-2 (2R,3R/S)-5-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-2-methylpentane-3-ol 

Downstream Products

• 915234-74-1 (2R,4R,5S,6E,8S,9Z)-4-(tert-butyldimethylsilyloxymethyl)-5-hydroxy-1-(p-methoxybenzyloxy)-2,6,8-trimethylundeca-6,9-diene-3-one 
• 346708-25-6 (4S,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(E)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1,3-dimethyl-but-1-enyl]-6-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxane 
• 346708-27-8 (E)-(2R,3S,6R)-1-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(2S,4S,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4,6-dimethyl-hept-4-en-3-ol 
• 346708-23-4 (E)-(2R,3S,4S,5S,8R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-2,6,8-trimethyl-non-6-ene-3,5-diol 
• 346708-18-7 (1S,2S,3S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-4-methyl-1-[(2R,3R)-2-methyl-3-((Z)-(S)-1-methyl-but-2-enyl)-oxiranyl]-pentane-1,3-diol 
• 346708-30-3 (E)-(R)-4-{(4S,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-6-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-pent-3-en-1-ol 
• 346708-32-5 (1'E,1''R,3'S,4S,4'Z,5S,6S)-5-(tert-butyldimethylsilyloxymethyl)-4-(1',3'-dimethylhexa-1',4'-dienyl)-6-[2''-(p-methoxybenzyloxy)-1''-methylethyl]-2,2-dimethyl-[1,3]dioxane 
• 346708-31-4 (E)-(R)-4-{(4S,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-6-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-pent-3-enal 
• 346708-33-6 (2R,3S,4S,5S,6E,8S,9Z)-4-(tert-butyldimethylsilyloxymethyl)-1-(p-methoxybenzyloxy)-2,6,8-trimethylundeca-6,9-diene-3,5-diol 
• 346708-22-3 (E)-(2R,4R,5S,8R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-1-(4-methoxy-benzyloxy)-2,6,8-trimethyl-non-6-en-3-one 

Relevant academic research and scientific papers

The total synthesis of (+)-tedanolide - A macrocyclic polyketide from marine sponge tedania ignis

Tedanolide, which was isolated by Schmitz in 1984 from the marine sponge Tedania ignis, is a highly cytotoxic macrolide leading to strong growth inhibition of P338 tumor cells in bioassays. A unique structural feature of the known tedanolides is the prima

Synthetic studies towards the total synthesis of tedanolide: Formation of the C(13)-C(23) fragment

The C(13)-C(23) subunit of tedanolide was obtained using a boron-mediated aldol reaction as the key step to control the C16 and C17 stereocenters.