346708-32-5Relevant academic research and scientific papers
The total synthesis of (+)-tedanolide - A macrocyclic polyketide from marine sponge tedania ignis
Ehrlich, Gunnar,Hassfeld, Jorma,Eggert, Ulrike,Kalesse, Markus
experimental part, p. 2232 - 2247 (2009/04/07)
Tedanolide, which was isolated by Schmitz in 1984 from the marine sponge Tedania ignis, is a highly cytotoxic macrolide leading to strong growth inhibition of P338 tumor cells in bioassays. A unique structural feature of the known tedanolides is the prima
Synthetic studies towards the total synthesis of tedanolide: Formation of the C(13)-C(23) fragment
Loh, Teck-Peng,Feng, Li-Chun
, p. 3223 - 3226 (2007/10/03)
The C(13)-C(23) subunit of tedanolide was obtained using a boron-mediated aldol reaction as the key step to control the C16 and C17 stereocenters.
