346718-90-9Relevant academic research and scientific papers
I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement
Patel, Shyam Sunder,Chandna, Nisha,Kumar, Shreemoyee,Jain, Nidhi
, p. 5683 - 5689 (2016/07/06)
A simple and efficient iodine-assisted protocol for the synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones has been developed. The reaction involves a sequential condensation followed by tandem oxidative cyclization and rearrangement of
Metal-Free Synthesis of 1,3,4-Oxadiazoles from N′-(Arylmethyl)hydrazides or 1-(Arylmethyl)-2-(arylmethylene)hydrazines
Shang, Zhenhua,Chu, Qianqian,Tan, Sheng
, p. 1032 - 1040 (2015/03/30)
An efficient and versatile metal-free synthesis of 1,3,4-oxadiazoles from N′-(arylmethyl)hydrazides or 1-(arylmethyl)-2-(arylmethylene)hydrazines through oxidative dehydrogenation is reported. A range of 2,5-disubstituted 1,3,4-oxadiazoles were prepared by treating N′-(arylmethyl)hydrazides with (diacetoxyiodo)benzene in acetonitrile or by treating 1-(arylmethyl)-2-(arylmethylene)hydrazines with [bis(trifluoroacetoxy)iodo]benzene in methyl tert-butyl ether. Aldehyde N-acylhydrazones and aldazines were initially generated in situ as intermediates.
Novel synthesis, characterisation and antitumour activity of dimethyl-3,6-di(aryl)-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboxylates
Lv, Lu-Ping,Zhou, Xiao-Feng,Shi, Hai-Bo,Gao, Jian-Rong,Hu, Wei-Xiao
, p. 368 - 370 (2014/07/08)
A series of new dimethyl-3,6-di(aryl)-1,4-dihydro-1,2,4,5-tetrazine-1,4- dicarboxylates were synthesised through an intermolecular cyclisation reaction of methyl N'-(a-chloro-substituted benzylidene) hydrazinecarboxylate and triethylamine. Their 1,4-dihyd
