34696-31-6

Upstream product

• 75238-29-8 3,5-dihydroxy-4-methylbenzoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 28026-96-2 3,5-dihydroxy-4-methylbenzoic acid 
• 3899-19-2 2,5-dihydroxy-4-methylbenzoic acid methyl ester 

Downstream Products

• 34696-32-7 4-methyl-3,5-dibenzyloxybenzoic acid 
• 99053-60-8 (3,5-bis(benzyloxy)-4-methylphenyl)methanol 
• 75238-29-8 3,5-dihydroxy-4-methylbenzoic acid methyl ester 

Relevant academic research and scientific papers

Preparation of tricyclic analog as CDE ring model of renieramycin marine natural product by novel photo-induced transformation of 6-methoxy-1,2,3,4-tetrahydroisoquinoline-5,8-dione

2-Acetyl-6-[(benzyloxy)methyl]-9-methoxy-8-methyl-11,11adihydro-2H-pyrazino[1,2-b]isoquinoline-1,4,7,10(3H,6H)-tetraone (11a) was prepared as the CDE ring model of renieramycins, and its novel photo-induced transformation was demonstrated to construct a 1,3-dioxol ring.

Effect of methyl substitution on the antioxidative property and genotoxicity of resveratrol

Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin with various biological activities including inhibition of lipid peroxidation and free radical scavenging properties. In addition to its beneficial effects, resveratrol also has significant genotoxicity that leads to a high frequency of chromosome aberration together with micronucleus and sister chromatid exchanges. To enhance the radical scavenging activities and to reduce the genotoxicity of resveratrol, we designed 4′-methyl resveratrol analogues where a methyl group was introduced at the ortho position relative to the 4′-hydroxy group, which is responsible for both antioxidative activities and genotoxicity of resveratrol. These synthesized methyl analogues of resveratrol showed increased antioxidative activities against galvinoxyl radical as an oxyl radical species. Furthermore, the methyl analogues also surprisingly showed reduced in vitro genotoxicities, suggesting that methyl substitution may improve resveratrol efficacy.