3470-90-4Relevant academic research and scientific papers
Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2
Lee, Yuseop,Choi, Jonghoon,Kim, Hyunwoo
supporting information, p. 5036 - 5039 (2018/08/24)
A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.
Catalytic metallodendrimers grafted on mesoporous polymethacrylate beads for the regioselective synthesis of β-amino alcohols under solvent-free conditions
Tiwari, Richa,H. Daware, Sachdeo,Kale, Sandeep B.
, p. 42526 - 42535 (2015/05/20)
A new series of dendritic structures was grafted on epoxy activated mesoporous polymethacrylate beads (Sepabeads EB-EP-400). Grafting with the dendritic structures was followed by loading of metal termini to the chelating groups to form metallodendrimer-g
Microwave-enhanced catalyst-free aminolysis of epoxides with anilines in aqueous phase: Efficient synthesis of β-amino secondary alcohols
Du, Zhengyin,Zhang, Wenwen,Zhang, Yuanmin,Wei, Xiaohong
experimental part, p. 726 - 728 (2012/03/09)
β-Amino secondary alcohols were formed by aminolysis of epichlorohydrin and styrene oxide with aromatic amines using aqueous ethanol (1:1) as the solvent in conjunction with microwave irradiation without a catalyst. The methodology is fast, efficient, hig
Activation and reactivity of epoxides on solid acid catalysts
Saikia,Satyarthi,Srinivas,Ratnasamy
, p. 148 - 160 (2008/09/18)
The aminolysis of epoxides over novel solid catalysts (Broensted-acidic SBA-15 functionalized with propylsulfonic acid and Lewis-acidic Ti-MCM-41) is reported. The acidic properties of these catalysts were determined by FTIR spectroscopy and temperature-programmed desorption of pyridine and NH3, respectively. The mesoporous solid acids of the present study are reusable and exhibit significantly higher catalytic activities than known catalysts for opening of the oxirane ring with nitrogen (aromatic and aliphatic amines)-containing and oxygen (alcohols)-containing nucleophiles. A range of β-amino alcohols with high regioselectivity and stereoselectivity were synthesized. Adsorption studies as well as the sigmoid shape of the conversion-versus-time plots show that the epoxide and amine compete for adsorption on the acidic sites ({single bond}SO3H or Ti4+) on the catalyst surface. Epoxide adsorption and activation on acid sites are the more critical processes. Catalytic activity decreases with increasing basicity of the amines and/or the alcohol, as well as the dielectric constant of the solvent.
