34701-88-7

Basic information

• Product Name: 2-iodo-3,4,5,6-tetramethylbenzoic acid
• Synonyms: 2-iodo-3,4,5,6-tetramethylbenzoic acid
• CAS NO: 34701-88-7
• Molecular Weight: 304.128
• Mol File: 34701-88-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-iodo-3,4,5,6-tetramethylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-3,4,5,6-tetramethylbenzoic acid(34701-88-7)
• EPA Substance Registry System: 2-iodo-3,4,5,6-tetramethylbenzoic acid(34701-88-7)

Safety Data

• Hazardous Substances Data: 34701-88-7(Hazardous Substances Data)

Upstream product

• 95-93-2 1,2,4,5-tetramethylbenzene 
• 2142-79-2 2,3,5,6-tetramethylacetophenone 
• 2529-39-7 2,3,4,5-tetramethylbenzoic acid 
• 34764-71-1 2',3',4',5'-tetramethylacetophenone 

Relevant articles and documents

Twist does a twist to the reactivity: Stoichiometric and catalytic oxidations with twisted tetramethyl-IBX

The methyl groups in TetMe-IBX lower the activation energy corresponding to the rate-determining hypervalent twisting (theoretical calculations), and the steric relay between successive methyl groups twists the structure, which manifests in significant solubility in common organic solvents. Consequently, oxidations of alcohols and sulfides occur at room temperature in common organic solvents. In situ generation of the reactive TetMe-IBX from its precursor iodo-acid, i.e., 3,4,5,6-tetramethyl-2-iodobenzoic acid, in the presence of oxone as a co-oxidant facilitates the oxidation of diverse alcohols at room temperature.