34701-98-9

Basic information

• Product Name: 2-chloro-4'-phenylbenzophenone
• Synonyms: 2-chloro-4'-phenylbenzophenone;Methanone, (1,1-biphenyl)-4-yl(2-chlorophenyl)-;1,1'-Biphenyl-4-yl(2-chlorophenyl)methanone
• CAS NO: 34701-98-9
• Molecular Formula: C₁₉H₁₃ClO
• Molecular Weight: 292.75892
• EINECS: 252-160-8
• Mol File: 34701-98-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 449°Cat760mmHg
• Flash Point: 259°C
• Appearance: /
• Density: 1.195g/cm³
• CAS DataBase Reference: 2-chloro-4'-phenylbenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4'-phenylbenzophenone(34701-98-9)
• EPA Substance Registry System: 2-chloro-4'-phenylbenzophenone(34701-98-9)

Safety Data

• Hazardous Substances Data: 34701-98-9(Hazardous Substances Data)

Usage

General Description

2-chloro-4'-phenylbenzophenone, also known as BP-4, is a chemical compound commonly used as an ingredient in sunscreens and other cosmetic products to protect the skin from UV radiation. It is a benzophenone derivative that absorbs UVB and short UVA rays, helping to prevent skin damage and sunburn. However, there has been some concern about the safety of BP-4, as it has been found to have potential endocrine-disrupting effects and may contribute to environmental pollution. As a result, some regulatory bodies have restricted its use in certain products, and the search for alternative UV filters with better safety profiles continues.

Upstream product

• 92-52-4 biphenyl 
• 609-65-4 o-chlorobenzoyl chloride 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 19063-39-9 3-phenyl-9H-fluoren-9-one 
• 103049-25-8 3-biphenyl-4-yl-3-(2-chloro-phenyl)-2-(4-chloro-phenyl)-acrylonitrile 
• 79446-82-5 3-Biphenyl-4-yl-3-(2-chloro-phenyl)-3-hydroxy-propionic acid ethyl ester 
• 42074-52-2 4-Diphenylyl-phenyl-o-chlorphenyl-methylchlorid 
• 79446-89-2 3-Biphenyl-4-yl-3-(2-chloro-phenyl)-3-hydroxy-propionic acid 
• 79446-89-2 3-Biphenyl-4-yl-3-(2-chloro-phenyl)-3-hydroxy-propionic acid 
• 79446-89-2 (R)-3-Biphenyl-4-yl-3-(2-chloro-phenyl)-3-hydroxy-propionic acid 
• 34974-11-3 4-Diphenylyl-phenyl-o-chlorphenylcarbinol 

Relevant articles and documents

Crystal structures of two 4-phenylbenzophenones

Two 4-phenylbenzophenones (I) and (II) are synthesized via Friedel-Crafts reactions. There are four crystallographically independent molecules with different conformations in the crystal structure of [1,1′-biphenyl]-4- yl(2-chlorophenyl)methanone (I). Crystals are orthorhombic, Pca21, C19H13ClO, a = 13.699(3) A, b = 8.9385(17) A, c = 46.836(9) A; V = 5735(2) A3, Z = 16, d x = 1.356 g/cm3. Torsion angles between the biphenyl rings are between 28.5 and 30.8. Several C-H.O and C-H.Cl hydrogen bonds and weak π-π stacking contacts consolidate the crystal. Crystals of [1,1′-biphenyl]-4- yl(3-methoxyphenyl)methanone (II) are orthorhombic, Pbca, C20H 16O2, a = 7.8179(15) A, b = 16.003(3) A, c = 23.345(5) A; V = 2920.7(10) A3, Z = 8, d x = 1.311 g/cm3. The torsion angle between the biphenyl rings is 28.1 and C-H.O hydrogen bonds are observed in compound (II).

Insertion of arynes into carbon-halogen σ-bonds: Regioselective acylation of aromatic rings

Arynes were found to insert into carbon-halogen σ-bonds of various acid halides, enabling acyl and halogen moieties to be introduced simultaneously into adjacent positions of aromatic rings. The Royal Society of Chemistry.