34708-67-3

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 105-53-3 diethyl malonate 

Downstream Products

• 1092074-24-2 C₂₂H₂₁F₃O₅ 
• 1092074-23-1 C₂₁H₂₁FO₅ 
• 1092074-25-3 C₂₂H₂₁F₃O₅ 
• 1092074-22-0 C₂₂H₂₄O₅ 
• 99558-35-7 diethyl 3-allyloxybenzylidenemalonate 
• 99558-36-8 4-(3-Allyloxy-phenyl)-5-ethoxy-dihydro-furan-2-one 
• 99558-37-9 5-(3-alloxyphenyl)pyridazin-3(2H)-one 

Relevant academic research and scientific papers

Lewis acidic ionic liquids for the synthesis of electrophilic alkenes via the Knoevenagel condensation

1-Butyl-3-methylimidazolium chloroaluminate, [bmim]Cl·AlCl3, N = 0.67 and 1-butylpyridinium chloroaluminate, [bpy]Cl·AlCl3, N = 0.67 ionic liquids were found to work well as the Lewis acid catalyst and solvent in the Knoevenagel condensations of benzaldehyde and substituted benzaldehydes with diethyl malonate to give benzylidene malonates. The benzylidene malonates subsequently underwent Michael additions with diethyl malonate. The extent of Michael product formed during the reaction was found to vary with the Lewis acidity and the molar proportion of ionic liquid. The influence of Lewis acidity of the ionic liquid on the Knoevenagel and Michael products is demonstrated. In the case of 2-hydroxyarylaldehydes, the reactions led to the formation of 3-ethoxycarbonyl coumarins under ambient conditions.

Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation

The identification of a novel pyrazolidine-3,5-dione based scaffold hit compound as Farnesoid X receptor (FXR) partial or full agonist has been accomplished by means of virtual screening techniques. A series of pyrazolidine-3,5-dione derivatives (1a-u and

Quinoline derivatives and medicinal use thereof

A quinoline derivative represented by the following formula (1): allows PPARα or γ which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various diseases related to PPARα or γ.

PREPARATION AND SOME REACTIONS OF 4- AND 5-ARYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONES

Efficient preparations of 4- and 5-phenyl-4,5-dihydropyridazin-3(2H)-ones have been developed, the main reactions of these compounds have been studied, and the synthetic routes have been used to give analogues with substituents in the phenyl rings.In the best synthesis of the 4-phenyldihyropyridazinone (72 percent overall yield) the product was obtained from phenylacetic acid by three simple stages.This approach was applied in preparations of the 2- and 4-hydroxyphenyl compounds and, in conjunction with a recent method for amine protection, the 4-aminophenyl analogue.A four stage synthesis starting from benzaldehyde gave the 5-phenyldihydropyridazinone in 47 percent overall yield; hydroxybenzaldehydes were similarly converted into 5-(allyloxyphenyl)dihydropyridazinones.Oxidation to phenylpyridazinones occured more readily with the 4- and 5-phenyldihydropyridazinones than with the 6-phenyl isomer.The 4- and 5-dihydropyridazinones were smoothly reduced to tetrahydropyridazinones by hydrogenation over platinum but were uneffected by palladium in the presence of hydrazine or cyclohexene.