34709-44-9

Usage

Uses

Used in Pharmaceutical Industry:
5-[(2-hydroxyphenyl)methylidene]-2-thioxo-1,3-thiazolidin-4-one is used as a pharmaceutical compound for its potential therapeutic properties. Its unique structure and reactivity make it a promising candidate for the development of new drugs and treatments.
Used in Organic Synthesis:
In the field of organic synthesis, 5-[(2-hydroxyphenyl)methylidene]-2-thioxo-1,3-thiazolidin-4-one serves as a key intermediate or building block. It can be utilized in the synthesis of a variety of complex organic compounds, contributing to the advancement of chemical research and development.
Used in Material Science:
5-[(2-hydroxyphenyl)methylidene]-2-thioxo-1,3-thiazolidin-4-one is also used in material science for its potential applications in creating new materials with unique properties. Its versatility allows it to be incorporated into various materials, enhancing their performance and functionality.

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-02-8 salicylaldehyde 

Downstream Products

• 852311-72-9 4-Hydrazono-5-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-thiazolidine-2-thione 
• 81154-06-5 E-5-(2-hydroxyphenylmethylene)-2-morpholino-4-oxo-2-thiazoline 

Relevant academic research and scientific papers

Synthesis and applications of some new nitrogen-containing heterocyclic azo-disperse dyes bearing quinoline chromophore

A set of five novel nitrogen-containing heterocyclic azo-disperse dyes 8 (a–d) and 10 were synthesized by diazotization of 4-bisaminoquinolines 3, followed by coupling either with rhodanine analogues 6 modified at C-5 position or α-naphthol 9. The chemica

Synthesis, molecular modeling, selective aldose reductase inhibition and hypoglycemic activity of novel meglitinides

In the present study, a novel generation of selective aldose reductase ALR2 inhibitors with significant hypoglycemic activities was designed and modulated based on rhodanine scaffold joined to an acetamide linker in between two lipophilic moieties. The synthesis of the novel compounds was accomplished throughout simple chemical pathways. Molecular docking was performed on B-cell membrane protein SUR1, aldehyde reductase ALR1 and aldose reductase ALR2 active sites. Compounds 10B, 11B, 12B, 15C, 16C, 26F and 27F displayed the highest hypoglycemic activities with 80.7, 85.2, 87, 82.3, 83.5, 81.4 and 85.3% reduction in blood glucose levels, respectively. They were more potent than the standard hypoglycemic agent repaglinide with 65.4% reduction in blood glucose level. Compounds 12B and 15C with IC50 0.29 and 0.35 μM were more potent than the standard ALR2 inhibitor epalrestat with IC50 0.40 μM. They were selective towards ALR2 over ALR1 134 and 116 folds, respectively. Molecular docking studies matched with the in-vitro and in-vivo results to elucidate the dual activities of both compounds 12B and 15C as potent antagonists for ALR2 over ALR1 and good agonists for the SUR1 protein.

Synthesis, structure analysis, investigation of conductivity, thermal properties of polyphenol derivatives containing a rhodanine moiety and their Cu(II), VO(IV) complexes

In this study, 5-benzylidenerhodanine derivatives namely 5-(2-hydroxybenzylidene)-2-thioxothiazolidin-4-one (SAR) and 5-((2-hydroxynaphthalen-1-yl)methylene)-2-thioxothiazolidin-4-one (HNAR) used as monomer. The new polymers of SAR and HNAR (PSAR and PHNA

Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors

A series of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited

A solvent-free protocol for the green synthesis of arylalkylidene rhodanines in a task-specific ionic liquid

2-Hydroxyethylammonium formate acts as a task-specific ionic liquid (TSIL) for the Knoevenagel condensation of carbonyl compounds with rhodanine to afford arylalkylidene rhodanines under solvent-free conditions and in good-to-excellent yields. Additionally, compared with those in organic solvents, the yields obtained in the presence of our ionic liquid (IL) were significantly increased. The detailed mechanism of the catalytic effect of TSIL is also reported for the first time.

Facile synthesis of 5-benzylidene rhodamine derivatives under microwave irradiation

A series of 5-benzylidenerhodamine derivatives were synthesized by the cross-aldol condensation of an aromatic aldehyde with rhodamine or rhodamine acetic acid in sodium acetate/acetic acid under microwave irradiation. The reaction was completed in 8-20 min with 63-94% yields and was environmentally benign with easy workup. Copyright Taylor & Francis Group, LLC.

Microwave induced synthesis of 3/4-substituted-2-thioxo/2-oxo -6-thioxo-1,2,3,4,6,7-hexahydrothiazolo [4, 5-d] pyrimidine and thiazole derivatives

The desired pyrimidine derivative (3/4), 3-H-2-thioxo-4-hydrazino-5- benzylidin-1, 3-thiazoles 5 and corresponding schiff bases 6 have been synthesized by microwave irradiation as well as by conventional method. The yields obtained with microwave conditio