34712-15-7 Usage
Uses
Used in Organic Synthesis:
2,3-dichloro-6H-indolo[2,3-b]quinoxaline is utilized as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for the formation of diverse chemical entities, making it a valuable component in the synthesis of specialty chemicals and pharmaceuticals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-dichloro-6H-indolo[2,3-b]quinoxaline is employed as a building block for the design and synthesis of new pharmaceutical compounds. Its biological activity and potential therapeutic uses are currently under investigation, with ongoing research aimed at uncovering its full spectrum of applications in drug development.
Used in Drug Development:
2,3-dichloro-6H-indolo[2,3-b]quinoxaline is explored as a prospective candidate in drug development due to its inherent biological activity. 2,3-dichloro-6H-indolo[2,3-b]quinoxaline's structure and properties make it a promising target for the creation of novel therapeutic agents, with the potential to address unmet medical needs across various health conditions.
Research and Development:
The ongoing research on 2,3-dichloro-6H-indolo[2,3-b]quinoxaline is focused on expanding its potential applications across different industries. Efforts are being made to understand its interactions with biological systems and to optimize its synthesis for improved yield and purity, thereby enhancing its utility in creating innovative products and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 34712-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,7,1 and 2 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 34712-15:
(7*3)+(6*4)+(5*7)+(4*1)+(3*2)+(2*1)+(1*5)=97
97 % 10 = 7
So 34712-15-7 is a valid CAS Registry Number.
34712-15-7Relevant academic research and scientific papers
Li, Wengang,Samra, Dina Abu,Merzaban, Jasmeen,Khashab, Niveen M.
, p. 1399 - 1402 (2013)
Multi-drug resistance (MDR) is a trend whereby tumor cells exposed to one cytotoxic agent develop cross-resistance to a range of structurally and functionally unrelated compounds. P -glycoprotein (P -gp) efflux pump is one of the mostly studied drug carrying processes that shuttle the drugs out of tumor cells. Thus, P -gp inhibitors have attracted a lot of attention as they can stop cancer drugs from being pumped out of target cells with the consumption of ATP. Using quantitive structure activity relationship (QSAR), we have successfully synthesized a series of novel P -gp inhibitors. The obtained dihydropyrroloquinoxalines series were fully characterized and then tested against bacterial and tumor assays with over-expressed P -gps. All compounds were bioactive especially compound 1c that had enhanced antibacterial activity. Furthermore, these compounds were utilized as targeting vectors to direct drug delivery vehicles such as silica nanoparticles (SNPs) to cancerous Hela cells with over expressed P -gps. Cell uptake studies showed a successful accumulation of these decorated SNPs in tumor cells compared to undecorated SNPs. The results obtained show that dihydropyrroloquinoxalines constitute a promising drug candidate for targeting cancers with MDR. Copyright
