347190-91-4Relevant academic research and scientific papers
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani
Stephens, Chad E.,Brun, Reto,Salem, Manar M.,Werbovetz, Karl A.,Tanious, Farial,Wilson, W. David,Boykin, David W.
, p. 2065 - 2069 (2003)
The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.
Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
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Page/Page column 9, (2008/06/13)
The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the appli
Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents
Stephens,Tanious,Kim,Wilson,Schell,Perfect,Franzblau,Boykin
, p. 1741 - 1748 (2007/10/03)
Dicationic 2,5-bis(4-guanidinophenyl)furans 5a-5f, 2,5-bis[4- (arylimino)aminophenyl]furans 6a-6b and 6e-6k, and 2,5-bis[4-(alkylimino)aminophenyl]furans 6c-6d have been synthesized starting from 2,5-bis[tri-n-butylstannyl]furan. Thermal melting studies w
