347335-63-1Relevant academic research and scientific papers
Synthesis of 2,4-diarylquinolines: Nickel-catalysed ligand-free cross-couplings of 4-chloro-2-arylquinolines with arylmagnesium halides in 2-methyltetrahydrofuran
Li, Zhenhua,Xu, Lingmin,Su, Weike
scheme or table, p. 240 - 242 (2011/07/29)
A ligand-free and room temperature protocol for the synthesis of 2,4-diarylquinolines is described. Treatment of 4-chloro-2-arylquinolines with arylmagnesium halides in the presence of a catalytic amount of nickel(II) chloride without ligands in 2-methylt
The Vilsmeier cyclization of 2′-azido and 2′-aminochalcones - A mild one pot synthesis of 2-aryl-4-chloroquinoline and its N-formyl-1,2-dihydro derivatives
Akila, Shanmugam,Selvi, Srinivasan,Balasubramanian, Krishna
, p. 3465 - 3469 (2007/10/03)
The Vilsmeier cyclization of 2′-aminochalcones provides a mild one pot synthesis of 2-aryl-4-chloro-N-formyl-1,2-dihydroquinolines. The scope of the reaction has been extended for the synthesis of quinolines themselves, by replacing 2′-aminochalcones with 2′-azidochalcones as the starting material. The yields are reasonably good and a plausible mechanism for the formation of the products in each case has been discussed.
