34734-28-6

Upstream product

• 1198007-41-8 N-(2-bromophenyl)-N'-(2,4,6-trimethylphenyl)formamidine 
• 51-17-2 benzoimidazole 
• 108-67-8 1,3,5-trimethyl-benzene 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 583-53-9 2,3-dibromobenzene 
• 88-05-1 2,4,6-trimethylaniline 
• 937807-96-0 N₁-mesityl-N₂-(diphenylmethylene)benzene-1,2-diamine 
• 28448-17-1 N-(2’,4’,6’-trimethylphenyl)-1,2-phenylenediamine 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 937807-73-3 1-methyl-3-(2,4,6-trimethylphenyl)-3H-benzimidazol-1-ium iodide 
• 1422557-70-7 3-[2-{[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]amino}-2-oxoethyl]-1-(2,4,6-trimethylphenyl)-1H-benzimidazolium chloride 

Relevant academic research and scientific papers

Green synthesis of CuO nanoflakes from copper pincer complex for effective N-arylation of benzimidazole

Nanostructured CuO is synthesized in water using copper pincer complex as precursor without any stabilizing agent and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-

Dehydrogenative Azolation of Arenes in a Microflow Electrochemical Reactor

The electrochemical synthesis of aryl azoles was performed for the first time in a microflow reactor. The reaction relies on the anodic oxidation of the arene partners making these substrates susceptible for C-H functionalization with azoles, thus requiring no homogeneous transition-metal-based catalysts. The synthetic protocol benefits from the implementation of a microflow setup, leading to shorter residence times (10 min), compared to previously reported batch systems. Various azolated compounds (22 examples) are obtained in good to excellent yields.

Copper-catalyzed synthesis of 2-unsubstituted, N-substituted benzimidazoles

(Chemical Equation Presented) An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-tert-butylphenyl and tolerating various functional groups demonstrate the utility of this method.

Highly stereoselective formal [3 + 3] cycloaddition of enals and azomethine imines catalyzed by N-heterocyclic carbenes

N-Heterocyclic carbenes derived from N-mesityl benzimidazolium salts are effective catalysts for generating homoenolate species from α,β-unsaturated aldehydes. The nucleophilic intermediate adds to azomethine imines, and the resulting activated carbonyl u