347374-56-5Relevant academic research and scientific papers
Substituted piperazine derivatives as mtp inhibitors
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, (2008/06/13)
The present invention relates to substituted piperazine derivatives of general formula wherein Ra to Rc, Ya, Yb, X and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
Combination of MTP inhibitors or apoB-secretion inhibitors with fibrates for use as pharmaceuticals
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, (2008/06/13)
The invention relates to the use of fibrates for lowering the liver toxicity of MTP inhibitors as well as pharmaceutical compositions containing an MTP inhibitor and a fibrate.
