347382-77-8 Usage
General Description
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine is a chemical compound that belongs to the phenylalanine family. It is a derivative of phenylalanine with two methoxy groups attached to the phenyl ring. (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine is commonly used in the field of medicinal chemistry and drug development due to its potential pharmacological activities. The presence of the methoxy groups can influence the compound's biological activity and provide opportunities for drug optimization. Additionally, (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine may also be used as a research tool in studying the structure-activity relationships of different drug molecules. Overall, this compound is of interest to scientists and researchers in the pharmaceutical industry for its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 347382-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,7,3,8 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 347382-77:
(8*3)+(7*4)+(6*7)+(5*3)+(4*8)+(3*2)+(2*7)+(1*7)=168
168 % 10 = 8
So 347382-77-8 is a valid CAS Registry Number.
347382-77-8Relevant articles and documents
Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY
Papst, Stefanie,Noisier, Anais F.M.,Brimble, Margaret A.,Yang, Yi,Krissansen, Geoffrey W.
, p. 5139 - 5149 (2012/11/07)
The α4β7 integrin is a well-known target for the development of drugs against various inflammatory disease states including inflammatory bowel disease, type 1 diabetes and multiple sclerosis. The synthesis of a small library of cell-permeable β7 integrin inhibitors based on the peptide biotin-R8ERY is reported, in which the tyrosine residue has been modified by using the Suzuki-Miyaura cross-coupling reaction. The synthesised peptidomimetics were evaluated in a cell adhesion assay and shown to inhibit Mn2+-activated adhesion of mouse TK-1 T cells to mouse MAdCAM-1. All of the synthesised peptidomimetics are more active than our previously reported lead compound biotin-R8ERY with two of the analogues, 6 and 7, exhibiting IC50 values of 15 μM.
