347382-77-8 Usage
Uses
Used in Medicinal Chemistry and Drug Development:
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine is used as a key compound in medicinal chemistry and drug development due to its potential pharmacological activities. The presence of methoxy groups allows for the exploration of structure-activity relationships and the optimization of drug molecules, enhancing their efficacy and safety profiles.
Used as a Research Tool:
In the pharmaceutical industry, (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine serves as an essential research tool for studying the structure-activity relationships of various drug molecules. This understanding can lead to the development of more effective and targeted therapeutic agents.
Used in Drug Optimization:
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine is used as a building block for drug optimization in the pharmaceutical industry. The methoxy groups present in the structure can be manipulated to improve the compound's interaction with biological targets, potentially leading to more potent and selective drugs.
Used in Therapeutic Applications:
(L)-4-(2',6'-dimethoxyphenyl)-phenylalanine holds promise for therapeutic applications, as its unique structure and pharmacological properties may contribute to the development of novel treatments for various diseases and conditions. (L)-4-(2',6'-dimethoxyphenyl)-phenylalanine's potential to be optimized for specific therapeutic targets makes it a valuable asset in the search for new medicines.
Check Digit Verification of cas no
The CAS Registry Mumber 347382-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,7,3,8 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 347382-77:
(8*3)+(7*4)+(6*7)+(5*3)+(4*8)+(3*2)+(2*7)+(1*7)=168
168 % 10 = 8
So 347382-77-8 is a valid CAS Registry Number.
347382-77-8Relevant academic research and scientific papers
Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY
Papst, Stefanie,Noisier, Anais F.M.,Brimble, Margaret A.,Yang, Yi,Krissansen, Geoffrey W.
supporting information, p. 5139 - 5149 (2012/11/07)
The α4β7 integrin is a well-known target for the development of drugs against various inflammatory disease states including inflammatory bowel disease, type 1 diabetes and multiple sclerosis. The synthesis of a small library of cell-permeable β7 integrin inhibitors based on the peptide biotin-R8ERY is reported, in which the tyrosine residue has been modified by using the Suzuki-Miyaura cross-coupling reaction. The synthesised peptidomimetics were evaluated in a cell adhesion assay and shown to inhibit Mn2+-activated adhesion of mouse TK-1 T cells to mouse MAdCAM-1. All of the synthesised peptidomimetics are more active than our previously reported lead compound biotin-R8ERY with two of the analogues, 6 and 7, exhibiting IC50 values of 15 μM.
