347406-07-9Relevant academic research and scientific papers
NEW SULFONAMIDE DERIVATIVE
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Paragraph 0062, (2021/08/28)
PROBLEM TO BE SOLVED: To provide a new sulfonamide derivative with cholesterol lowering effect, neutral fat reduction effect, and FXR agonist effect that is expected to be effective for treatment of NAFLD and NASH, or a salt thereof, and pharmaceutical compositions containing them. SOLUTION: The invention provides: a new sulfonamide derivative, a typical example of which is 6-{4-[(N-isobutylphenylsulfonamide)methyl]-2-methoxyphenyl}-2-naphthalenecarboxylic acid (general formula (5) in the figure); a pharmaceutically acceptable salt thereof; and pharmaceutical compositions containing them. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
A one-pot oxidation-imine formation-reduction route from alcohols to amines using manganese dioxide-sodium borohydride: The synthesis of naftifine
Kanno, Hisashi,Taylor, Richard J.K.
, p. 7337 - 7340 (2007/10/03)
A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine.
In Situ Oxidation-Imine Formation-Reduction Routes from Alcohols to Amines
Blackburn, Leonie,Taylor, Richard J. K.
, p. 1637 - 1639 (2007/10/03)
(matrix presented) Manganese dioxide is employed as an in situ oxidant for the one-pot conversion of alcohols into imines. In combination with polymer-supported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence is reported. This procedure enables alcohols to be converted directly into both secondary and tertiary amines.
