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1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester, also known as baricitinib, is a pyrimidine carboxylic acid derivative with potential therapeutic applications. It functions as a selective inhibitor of Janus kinases, specifically JAK1 and JAK2, and has demonstrated efficacy in modulating immune system responses.

34750-63-5

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34750-63-5 Usage

Uses

Used in Pharmaceutical Industry:
Baricitinib is utilized as an immunomodulatory agent for the treatment of autoimmune diseases such as rheumatoid arthritis. Its ability to inhibit JAK1 and JAK2 enzymes helps in managing inflammation and immune system dysregulation associated with these conditions.
Used in COVID-19 Treatment:
In the context of COVID-19, baricitinib is employed to inhibit cytokine release and reduce inflammation, which can be beneficial in mitigating the severity of the disease and improving patient outcomes.
Used in Research and Development:
Baricitinib is also used in research settings to study its potential as a treatment for a variety of inflammatory and autoimmune conditions, expanding its applications beyond its current uses.

Check Digit Verification of cas no

The CAS Registry Mumber 34750-63-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,7,5 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 34750-63:
(7*3)+(6*4)+(5*7)+(4*5)+(3*0)+(2*6)+(1*3)=115
115 % 10 = 5
So 34750-63-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H11N3O3/c1-2-18-12(17)9-7-14-10(15-11(9)16)8-4-3-5-13-6-8/h3-7H,2H2,1H3,(H,14,15,16)

34750-63-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 6-oxo-2-pyridin-3-yl-1H-pyrimidine-5-carboxylate

1.2 Other means of identification

Product number -
Other names 4-Hydroxy-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34750-63-5 SDS

34750-63-5Relevant academic research and scientific papers

PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS

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Page/Page column 44-45, (2011/05/08)

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R1, R2, R3, and L, A, and Ra are defined herein.

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