1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester

Base Information

• Chemical Name: 1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester
• CAS No.: 34750-63-5
• Molecular Formula: C12H11N3O3
• Molecular Weight: 245.23404
• Hs Code.: 2933990090
• Mol file: 34750-63-5.mol

Synonyms:1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester;4-Hydroxy-2-(pyridin-3-yl)pyrimidine-5-carboxylic acid ethyl ester;5-PyriMidinecarboxylic acid, 1,6-dihydro-6-oxo-2-(3-pyridinyl)-, ethyl ester;Ethyl 1,6-dihydro-6-oxo-2-(3-pyridinyl)-5-pyriMidinecarboxylate

Chemical Property of 1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester

Chemical Property:

• PSA: 85.20000
• Density: 1.33
• LogP: 1.42090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-hydroxy-2-(pyridin-3-yl)pyrimidine-5-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester

There total 2 articles about 1,6-Dihydro-6-oxo-2-(3-pyridinyl)-5-pyrimidinecarboxylic acidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-pyridinecarboximidamide (23255-20-1) + diethyl 2-ethoxymethylenemalonate (87-13-8) → 4-oxo-2-pyridin-3-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester (34750-63-5)

Guidance literature:

3-pyridinecarboximidamide; With ethanol; sodium ethanolate; at 20 ℃; for 0.166667h;

diethyl 2-ethoxymethylenemalonate; In ethanol; at 0 - 20 ℃; for 5h;

With hydrogenchloride; In ethanol; water; pH=5;

Reference yield:

→ 4-oxo-2-pyridin-3-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester (34750-63-5)

Guidance literature:

3-Carbamidinopyridin*HCl, Dimethyl ethoxymethylenmalonat,NaOEt;

Reference yield:

4-oxo-2-pyridin-3-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester (34750-63-5) → 2-(S)-{[4-(3-cyano-phenoxy)-2-pyridin-3-yl-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (1298101-16-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 20 °C

1.2: Cooling

2.1: caesium carbonate / acetonitrile / 2 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

3.2: pH 2

4.1: triethylamine / 0.5 h / Molecular sieve; Inert atmosphere; Reflux

4.2: 3 h / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

6.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 20 °C

6.2: 26 h / 20 °C

With thionyl chloride; water; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;

upstream raw materials:

3-pyridinecarboximidamide

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

4-chloro-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester

4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester

4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid

[4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidin-5-yl]carbamic acid tert-butyl ester