34765-49-6

Upstream product

• 27052-11-5 2-(4-nitrophenylimino)thiazolidin-4-one 
• 100-52-7 benzaldehyde 
• 17329-87-2 2-chloro-N-(4-nitro-phenyl)-acetamide 
• 100-01-6 4-nitro-aniline 
• 3696-22-8 p-nitrophenylthiourea 

Downstream Products

• 847021-07-2 2-(2-{2-[(E)-4-Nitro-phenylimino]-4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-ethoxy)-isoindole-1,3-dione 
• 847021-16-3 2-(3-{2-[(E)-4-Nitro-phenylimino]-4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione 
• 847021-25-4 2-(4-{2-[(E)-4-Nitro-phenylimino]-4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-butoxy)-isoindole-1,3-dione 
• 847021-34-5 2-(4-nitro-phenylimino)-7-phenyl-2,3-dihydro-thiazolo[4,5-d]pyrimidin-5-ol 

Relevant academic research and scientific papers

Novel 2-(substituted phenyl Imino)-5-benzylidene-4-thiazolidinones as possible non-ulcerogenic tri-action drug candidates: synthesis, characterization, biological evaluation And docking studies

The present research was aimed at the synthesis and screening of 35 novel 2-(substituted phenyl imino)-5-benzylidene-4-thiazolidinones having different substitutions at imino phenyl and arylidene groups. The title compounds were synthesized by Knoevenagel

Syntheses and evaluation of 2,5-disubstituted 4-thiazolidinone analogues as antimicrobial agents

Two novel series of 4-thiazolidinone derivatives, bearing 2-nitrophenyl imino and 4-nitrophenyl imino groups at position-2 and substituted arylidene groups at position-5, have been synthesized and evaluated for antimicrobial activity against four bacteria

Synthesis and biological evaluation of 7-N-(n-alkoxyphthalimido)-2hydroxy- 4-aryl-6-aryliminothiazolidino [2,3-b] pyrimidines and related compounds

Substituted aryl thioureas 1a-c react with chloroacetic acid in the presence of anhydrous sodium acetate to furnish 2-aryliminothiazolidin-4-ones 2a-c. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2a-c give the corresponding alkoxyphthalimide derivatives of 2-aryliminothiazolidin-4-ones 4a-i. These on condensation with araldehydes 5a-c yield 3-N-(alkoxyphthalimido)- 5-arylidene-2-aryliminothiazolidin-4-ones 7a-a′. In an alternative route 5a-c react with 2a-c to give 6a-i, which could be cyclised with urea in the presence of sodium acetate to yield the corresponding thiazolidinopyrimidine 8a-i. 7a-a′ are also prepared from 6a-i with 3a-c, which give final compound 9a-a′ on cyclisation. Alternatively, 8a-i when condensed with 3a-c also furnish the compounds 9a-a′. Evaluation of antimalarial and antibacterial activity is also reported.