347851-57-4

Basic information

• Product Name: (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-hepten-1-ol
• Synonyms: (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-hepten-1-ol
• CAS NO: 347851-57-4
• Molecular Weight: 443.543
• Mol File: 347851-57-4.mol

Chemical Properties

• CAS DataBase Reference: (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-hepten-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-hepten-1-ol(347851-57-4)
• EPA Substance Registry System: (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-hepten-1-ol(347851-57-4)

Safety Data

• Hazardous Substances Data: 347851-57-4(Hazardous Substances Data)

Upstream product

• 347851-53-0 dimethyl [(3S)-4-phenyl-3-[(benzyloxycarbonyl)amino]-2-oxobutyl]phosphonate 
• 137685-80-4 methyl 2-benzyl-3-(t-butyldimethylsilyloxy)-propionate 
• 149524-96-9 2-(tert-butyldimethylsilanyloxymethyl)-3-phenylpropionaldehyde 
• 6811-98-9 (RS)-2-hydroxymethyl-3-phenylpropionic acid 
• 85677-12-9 2-benzyl-3-hydroxypropionic acid methyl ester 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 347851-56-3 tert-butyldimethylsilyl-(2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-heptenyl ether 

Relevant articles and documents

Design and synthesis of a conformationally restricted trans peptide isostere based on the bioactive conformations of saquinavir and nelfinavir

The design and synthesis of a new peptide isostere which contains a trans alkene core is described. The key step involves a Wadsworth-Emmons reaction between chiral aldehyde (2S)-9a and chiral phosphonate 7 under base-sensitive conditions to give a chiral enone (2R)-24a which was reduced to afford the desired trans alkene isosteres (2R,5R)-6a and (2R,5S)-6b (Scheme 6). A potential application of this isostere in the synthesis of HIV protease inhibitors is also discussed.