149524-96-9Relevant academic research and scientific papers
One-pot sequential 1,4- and 1,2-reductions of α,β-unsaturated δ-lactones to the corresponding δ-lactols with CuCl and NaBH 4 in methanol
Matsumoto, Yasunobu,Yonaga, Masahiro
supporting information, p. 1764 - 1768 (2014/08/05)
An efficient, one-pot method for the highly chemoselective synthesis of δ-lactols from α,β-unsaturated δ-lactones using CuCl and NaBH4 in methanol was developed. Georg Thieme Verlag Stuttgart. New York.
Chemoenzymatic synthesis of enantiomerically enriched α-chiral 3-oxy-propionaldehydes by lipase-catalyzed kinetic resolution and desymmetrization
Wiktelius, Daniel,Larsson, Emma K.,Luthman, Kristina
, p. 2088 - 2100 (2007/10/03)
Enantiomerically enriched phenylalanine- and leucine aldehyde analogues have been prepared by lipase catalyzed desymmetrization or kinetic resolution of 1,3-propanediol derivatives as key steps. Observations of unusual enantioselectivity were made, and mo
Design and synthesis of a conformationally restricted trans peptide isostere based on the bioactive conformations of saquinavir and nelfinavir
Edmonds,Abell
, p. 3747 - 3752 (2007/10/03)
The design and synthesis of a new peptide isostere which contains a trans alkene core is described. The key step involves a Wadsworth-Emmons reaction between chiral aldehyde (2S)-9a and chiral phosphonate 7 under base-sensitive conditions to give a chiral enone (2R)-24a which was reduced to afford the desired trans alkene isosteres (2R,5R)-6a and (2R,5S)-6b (Scheme 6). A potential application of this isostere in the synthesis of HIV protease inhibitors is also discussed.
Stereoselective Epoxidation of Phe-Gly and Phe-Phe Vinyl Isosteres
Jenmalm, Annika,Berts, Wei,Li, Yi-Lin,Luthman, Kristina,Csoeregh, Ingeborg,Hacksell, Uli
, p. 1139 - 1148 (2007/10/02)
Novel Phe-Gly and Phe-Phe isosteres have been synthesized.Vinylic isosteres of Phe-Gly and Phe-Phe were prepared by facile Julia reactions, and the resulting stereoisomers were isolated and epoxidized (m-chloroperbenzoic acid).Observed stereoselectivities
