347976-88-9Relevant academic research and scientific papers
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists
Chesworth, Richard,Zawistoski, Michael P.,Lefker, Bruce A.,Cameron, Kimberly O.,Day, Robert F.,Mangano, F. Michael,Rosati, Robert L.,Colella, Stacy,Petersen, Donna N.,Brault, Amy,Lu, Bihong,Pan, Lydia C.,Perry, Pia,Ng, Oicheng,Castleberry, Tessa A.,Owen, Thomas A.,Brown, Thomas A.,Thompson, David D.,DaSilva-Jardine, Paul
, p. 2729 - 2733 (2004)
Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER α and ER β selective analogs.
