Bioorganic and Medicinal Chemistry Letters p. 2729 - 2733 (2004)
Update date:2022-09-26
Topics:
Chesworth, Richard
Zawistoski, Michael P.
Lefker, Bruce A.
Cameron, Kimberly O.
Day, Robert F.
Mangano, F. Michael
Rosati, Robert L.
Colella, Stacy
Petersen, Donna N.
Brault, Amy
Lu, Bihong
Pan, Lydia C.
Perry, Pia
Ng, Oicheng
Castleberry, Tessa A.
Owen, Thomas A.
Brown, Thomas A.
Thompson, David D.
DaSilva-Jardine, Paul
Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER α and ER β selective analogs.
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