34800-35-6Relevant academic research and scientific papers
5-Iodo-3-ethoxypyrazoles: An entry point to new chemical entities
Guillou, Sandrine,Janin, Yves L.
experimental part, p. 4669 - 4677 (2010/08/06)
Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of ethyl 3-ethoxy-lW-pyrazole-4-carboxylate. This is based on the reaction of hydrazine monohydrochloride and diethyl 2-(ethoxymethylene)malonate. Further transformations of this key compound allowed the preparation of the two possible iodinated isomers, namely, 3-ethoxy-4-iodo- and 3-ethoxy-5-iodo-1H-pyrazole. These compounds have opened the way to a quick access to many original pyrazole series. As an illustration, we report here on the selectivity of N-arylation, by using the Lam and Cham method, the C4- and C5-arylation of some of these 3-ethoxy-pyrazole derivatives by using the Suzuki-Miyaura reaction, and C5-benzylation reactions by means of the Negishi reaction. This was followed by hydrolysis of the ethoxy group, which led to the corresponding pyrazol-3-one derivatives. As a conclusion of this work, we conducted an investigation into the regiochemistry of the condensation between diethyl 2-(ethoxymethylene) malonate and the hydrochloride salts of methyl, benzyl, or phenyl hydrazine.
Alkoxypyrazoles and the process for their preparation
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Page/Page column 26; 27, (2010/03/02)
The present invention relates to a process for the preparation of alkoxypyrazoles and new alkoxypyrazole compounds.
Pd-catalyzed cross-coupling reactions of halogenated 1-phenylpyrazol-3-ols and related triflates
Arba?iauskiene, Egle,Vilkauskaite, Gyte,Eller, Gernot A.,Holzer, Wolfgang,?a?kus, Algirdas
experimental part, p. 7817 - 7824 (2009/12/26)
1-Phenyl-1H-pyrazol-3-ol was used as a versatile synthon for the preparation of various 1-phenyl-1H-pyrazole derivatives substituted at C-3 and C-4 of the pyrazole nucleus and at the phenyl ring para-position. Treatment of 1-phenyl-1H-pyrazol-3-ol with tr
Novel pyrazolyloxyacetic acid derivatives and process for the preparation thereof
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, (2008/06/13)
Compounds of the formula SPC1 Wherein X and Y each are a bond or methylene, R is H or lower-alkyl and Z is a carboxyl, amide, nitrile or alkoxycarbonyl of 1-6 carbon atoms in the alkoxy group and the corresponding compounds bearing 1-2 halogen, lower-alkyl or lower-alkoxy groups on one or both benzene rings and, when Z is carboxyl, salts thereof with physiologically acceptable bases, possess anti-inflammatory and antipyretic activities.
