34801-14-4

Usage

Uses

Used in Pharmaceutical Development:
4-(5-Bromo-2-thienyl)-1,3-thiazol-2-amine is used as a building block or intermediate in the synthesis of pharmaceuticals for its potential biological activities. Its unique structure may contribute to the development of new drugs with specific therapeutic targets.
Used in Agrochemical Research:
In the agrochemical industry, 4-(5-Bromo-2-thienyl)-1,3-thiazol-2-amine is used as a chemical intermediate for the development of new pesticides or herbicides, leveraging its heterocyclic nature to target specific pests or weeds.
Used in Materials Science:
4-(5-Bromo-2-thienyl)-1,3-thiazol-2-amine is utilized as a component in the creation of new materials with unique properties, such as in the development of organic electronic devices or advanced polymers, due to its potential to influence material characteristics.
Safety and Handling:
4-(5-Bromo-2-thienyl)-1,3-thiazol-2-amine is used with caution in laboratory and industrial settings due to the presence of bromine, which requires adherence to safety protocols to prevent hazardous exposure or reactions.

InChI:InChI=1/C7H5BrN2S2/c8-6-2-1-5(12-6)4-3-11-7(9)10-4/h1-3H,(H2,9,10)

Upstream product

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Relevant academic research and scientific papers

Based on isoxazole substitution of benzamide derivatives and anti-prostate cancer drug applications

The present invention discloses a class (I), formula (II) structure based on isoxazole substituted benzamide derivatives and antiprostate cancer drug applications, such isoxazole substituted benzamide derivatives, can effectively inhibit the activity of a

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

Convenient and simple synthesis of 2-aminothiazoles by the reaction of α-halo ketone carbonyls with ammonium thiocyanate in the presence of N-methylimidazole

Substituted 2-aminothiazole derivatives were obtained as a result of N-methylimidazole catalyzed cyclization of α-halo ketone carbonyls with ammonium thiocyanate in water-alcoholic media. The generality of the method has been demonstrated by screening a series of aromatic/heteroaromatic/aliphatic α-halo ketones, α-halo β-diketones, and α-halo β-ketoesters. The developed method is simple, mild, and general route for the preparation of diversely functionalized 2-aminothiazoles in good to moderate yields from readily available starting materials.

BROMINATION OF 4-(2-THIENYL)THIAZOLES AND 2-(2-THIENYL)QUINOLINE

Depending on the substituent, the bromination of 4-(2-thienyl)thiazoles and 2-(2-thienyl)quinoline takes place in the 5 position of the thiophene or thiazole ring.When an amino group is present in the 2 position of the thiazole ring, bromination takes place in the 5 position of the thiazole ring.When excess brominating agent is present, a second bromine atom enters the 5 position of the free ring.