34839-70-8

Basic information

• Product Name: Thiourea,N-methyl-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-
• Synonyms: Thiourea,N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- (9CI); Metiamide;N-Methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea;N-Methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea; NSC 307755;SKF 92058
• CAS NO: 34839-70-8
• Molecular Formula: C9H16 N4 S2
• Molecular Weight: 244.3801
• EINECS: 200-258-5
• Mol File: 34839-70-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 463°Cat760mmHg
• Flash Point: 233.8°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 9.46E-09mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: Soluble in Water
• PKA: 14.14±0.10(Predicted)
• CAS DataBase Reference: Thiourea,N-methyl-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea,N-methyl-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-(34839-70-8)
• EPA Substance Registry System: Thiourea,N-methyl-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-(34839-70-8)

Safety Data

• Hazardous Substances Data: 34839-70-8(Hazardous Substances Data)

Usage

Uses

Antagonist (to histamine H2receptors).

InChI:InChI=1/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)

Upstream product

• 74-89-5 methylamine 
• 77582-13-9 4-(2-isothiocyanato-ethylsulfanylmethyl)-5-methyl-1⁽³⁾H-imidazole 
• 556-61-6 methyl thioisocyanate 
• 38585-67-0 4-methyl-5-<(2-aminoethyl)-thiomethyl>-imidazole 
• 38603-72-4 4-Methyl-5-[(2-amino-ethyl)thiomethyl]-imidazole dihydrochloride 

Downstream Products

• 51481-61-9 Cimetidine 

Relevant articles and documents

Preparation method of cimetidine

The invention discloses a preparation method of cimetidine. The preparation method comprises the following steps of (1) condensing 2-(4-methylimidazole-4-yl) methyl thioethylamine hydrochloride and CS2 in the presence of alkali, and preparing an intermediate (I) under the action of a desulfurization reagent, (2) reacting the intermediate (I) with monomethylamine to prepare an intermediate (II), and (3) in the presence of a desulfurization reagent, carrying out amination on the intermediate (II) and cyanamide to prepare cimetidine.

PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.

PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING H-1 AND H-2 HISTAMINE RECEPTORS

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. "