34840-27-2

Upstream product

• 2621-84-3 N-(ethoxycarbonyl)-2-nitroaniline 
• 88-74-4 2-nitro-aniline 
• 541-41-3 chloroformic acid ethyl ester 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 64-17-5 ethanol 
• 95-54-5 1,2-diamino-benzene 
• 56796-57-7 [2-(Dimethylamino-methyleneamino)-phenyl]-carbamic acid ethyl ester 
• 59103-39-8 1,3-dibenzyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 28643-53-0 1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one 
• 131637-19-9 1,3-dihydro-1-(2-propynyl)-2H-benzimidazol-2-one 

Relevant academic research and scientific papers

Synthesis of Novel Structurally Diverse N-Mono- and N,N′-Disubstituted Benzimidazol-2-one Derivatives by the Alkylations of 1,3-Dihydro-2H-benzimidazol-2-one with Some Alkyl Halides under Transfer Catalysis Conditions

A series of N-mono- and N,N′-disubstituted benzimidazol-2-one derivatives optionally substituted on both secondary amine functionalities were prepared with excellent yields by reacting 1,3-dihydro-2H-benzimidazol-2-one in one and two steps respectively with various alkyl halides under phase transfer catalytic conditions. One of the synthesized N,N-disubstituted benzimidazol-2-one derivatives underwent a regiospecific 1,3-dipolar cycloaddition reaction at its side allyl substituent with the in situ generated 4-chloro benzonitrile N-oxide from 4-chlorobenzaldoxime to afford in good yield the corresponding N,N′-disubstituted derivative incorporating the 2,5-dihydro-isoxazole nucleus in one of the side chain. All the new compounds were fully characterized by their physical and spectroscopic data.

Cardioselective Anti-Ischemic ATP-Sensitive Potassium Channel Openers. 3. Structure-Activity Studies on Benzopyranyl Cyanoguanidines: Modification of the Cyanoguanidine Portion

Structure-activity relationships for the cyanoguanidine portion of the lead cardiac selective ATP-sensitive potassium channel (KATP) opener (3) are described.The cyanoguanidine moiety appears to be optimal since increasing or decreasing the dis

4-SUBSTITUTED BENZOPYRAN AND RELATED COMPOUNDS

Compounds having the formula STR1 and pharmaceutically acceptable salts thereof. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.

Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents

A new method for the treatment of ischemic conditions and arrhythmia is disclosed. The method uses compounds of the formula STR1 wherein A can be --CH2 --, --O--, --NR9 --, --S--, --SO--, --SO2 --; X can be oxygen or sulfu