28643-53-0

Basic information

• Product Name: 1-Benzyl-1,3-dihydro-2H-benzimidazole-2-one
• Synonyms: 1-Benzyl-1,3-dihydro-2H-benzimidazole-2-one;1-Benzyl-2,3-dihydro-1H-benzimidazole-2-one;2,3-Dihydro-1-benzyl-1H-benzimidazol-2-one
• CAS NO: 28643-53-0
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 0
• Mol File: 28643-53-0.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyl-1,3-dihydro-2H-benzimidazole-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-1,3-dihydro-2H-benzimidazole-2-one(28643-53-0)
• EPA Substance Registry System: 1-Benzyl-1,3-dihydro-2H-benzimidazole-2-one(28643-53-0)

Safety Data

• Hazardous Substances Data: 28643-53-0(Hazardous Substances Data)

Upstream product

• 100969-46-8 1-benzyl-2-methanesulfonyl-1H-benzimidazole 
• 77556-98-0 1-Benzyl-3-(1-phenyl-vinyl)-1,3-dihydro-benzoimidazol-2-one 
• 100460-84-2 (2-Amino-phenyl)-benzyl-carbamic acid ethyl ester 
• 161468-70-8 Ethyl 2,3-dihydro-2-oxo-3-(phenylmethyl)-1H-benzimidazole-1-carboxylate 
• 31493-51-3 1-benzyl-1,3-dihydro-2H-benzo-[d]-imidazole-2-thione 
• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 620-05-3 iodomethylbenzene 
• 100-44-7 benzyl chloride 
• 90331-20-7 1-Benzylbenzimidazole-2-sulfonic Acid 
• 25216-70-0 2-bromophenyl carbamic acid methyl ester 
• 100-46-9 benzylamine 
• 40828-54-4 1H-benzimidazole-2-sulfonic acid 
• 41120-23-4 ethyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 77557-11-0 1-benzyl-3-butyl-1H-benzo[d]imidazol-2(3H)-one 
• 240143-51-5 3-benzyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid (2-chloro-ethyl)-amide 
• 75389-56-9 ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate 
• 75389-70-7 3-benzyl-2-oxo-1-benzimidazolineacetic acid 
• 65330-75-8 1-benzyl-2-(piperidin-1-yl)-1H-benzo[d]imidazole 
• 83421-97-0 8-(3-benzyl-2-oxo-benzimidazolin-1-yl)-caprylic acid methyl ester 
• 1227248-64-7 (3-benzyl-2-oxo-2,3-dihydrobenzoimidazol-1-yl)-acetic acid t-butyl ester 

Relevant articles and documents

Synthesis and antinociceptive activity of (1-benzyl-2(3H)- benzimidazolon-3-yl) acetic acid derivatives

Eight (1-benzyl-2(3H)-benzimidazolon-3-yl)acetic acid derivatives have been synthesized and tested for antinociceptive activity in this study. All compounds but one, at the oral dose of 100 mg/kg were comparable with aspirin. Ethyl (1-benzyl-2(3H)-benzimi

Synthesis of Benzimidazolones via One-Pot Reaction of Hydroxylamines, Aldehydes, and Trimethylsilyl Cyanide Promoted by Diacetoxyiodobenzene

A novel and efficient PhI(OAc)2-promoted one-pot reaction of aromatic hydroxylamines, aldehydes, and TMSCN in the presence of BF3·Et2O is described. A wide variety of N-substituted benzimidazolones are obtained with satisfactory yields under mild reaction conditions. The method was proven to be efficient for the synthesis of benzimidazolone derivatives from readily available starting materials.

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogues as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which have been known as the causative parasites for visceral leishmaniasis and Chagas disease, respectively. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds 4 and 24 showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, respectively) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 mM, respectively) without serious cytotoxicity toward THP-1 and U2OS cell lines.