34840-85-2

Basic information

• Product Name: 3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID
• Synonyms: 3-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPANOIC ACID;DL-BETA-(3,4-DIMETHOXYPHENYL)ALANINE;DL-3-AMINO-3-(3',4'-DIMETHOXYPHENYL)PROPIONIC ACID;RARECHEM AK HC T253;TIMTEC-BB SBB000651;SPECS AG-205/40088415;DL--(3,4-Dimethoxyphenyl)alanine;3-(3,4-DIMETHOXYPHENYL)-DL-BETA-ALANINE
• CAS NO: 34840-85-2
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.24
• Mol File: 34840-85-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 223 °C (dec.)(lit.)
• Boiling Point: 217°C
• Flash Point: 183.416 °C
• Appearance: /
• Density: 1.212 g/cm³
• CAS DataBase Reference: 3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID(34840-85-2)
• EPA Substance Registry System: 3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID(34840-85-2)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 34840-85-2(Hazardous Substances Data)

Usage

Uses

3-Amino-3-(3,4-dimethoxyphenyl)propanoic Acid can be used as a novel therapeutic candidate to induce γ-?globin producing HbF for anemia.

Upstream product

• 141-82-2 malonic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5763-61-1 3,4-dimethoxybenzylamine 
• 62334-34-3 C₉H₁₁NO₂ 

Downstream Products

• 34841-03-7 methyl 3-amino-3-(3',4'-dimethoxyphenyl)propionate hydrochloride 
• 54503-20-7 methyl 3-amino-3-(3,4-dimethoxyphenyl)propionate 
• 167887-02-7 3-phthalimido-3-(3',4'-dimethoxyphenyl)propionic acid 
• 54503-21-8 ethyl 3-amino-3-(3',4'-dimethoxyphenyl)propionate 
• 167886-75-1 3-(3,4-dimethoxyphenyl)-3-(1-oxoisoindolin-2-yl)propionic acid 
• 201408-35-7 3-amino-3-(3,4-dimethoxyphenyl)propan-1-ol 
• 1078052-80-8 methyl 5-(tert-butoxycarbonylamino)-5-(3,4-dimethoxyphenyl)-3-oxopentanoate 
• 1078052-82-0 C₂₃H₃₅NO₇ 
• 1078052-81-9 C₂₃H₃₅NO₇ 
• 1078052-83-1 C₁₇H₂₃NO₄ 
• 1078052-84-2 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one 
• 1078052-85-3 C₁₇H₂₅NO₄ 
• 1078052-79-5 C₁₇H₂₇NO₃ 
• 1078052-96-6 C₁₇H₂₁NO₄ 

Relevant articles and documents

First synthesis of racemic trans propargylamino-donepezil, a pleiotrope agent able to both inhibit AChE and MAO-B, with potential interest against Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxidase-B (MAO-B) appear as particularly convincing, especially if displayed by a sole agent such as ladostigil, currently in clinical trial in AD. Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). The synthesis of racemic trans PADPZ was achieved and its biological evaluation established its inhibitory activities towards both (h)AChE (IC50 = 0.4 μM) and (h)MAO-B (IC50 = 6.4 μM).

GLUCOSE METABOLISM MODULATING COMPOUNDS

The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyperglycemia.

Facile synthesis of N-(9-fluorenylmethyloxycarbonyl)-3-amino-3-(4,5- dimethoxy-2-nitrophenyl)propionic acid as a photocleavable linker for solid-phase peptide synthesis

A photocleavable linker, N-(9-fluorenylmethyloxycarbonyl)-3-amino-3-(4,5- dimethoxy-2-nitrophenyl)propionic acid was synthesized from veratraldehyde, with simple reaction and separation steps. This linker was stable under the normal solid-phase peptide sy