34847-16-0Relevant academic research and scientific papers
Recyclable Silica-Supported Iridium Catalysts for Selective Reductive Transformation of Quinolines with Formic Acid in Water
Zhang, Jing-Fan,Zhong, Rui,Zhou, Quan,Hong, Xi,Huang, Shuang,Cui, He-Zhen,Hou, Xiu-Feng
, p. 2496 - 2505 (2017/07/13)
Mesoporous silica (SBA-15)-supported iridium catalysts are prepared by grafting of the newly developed cyclometalated iridium 2-aryl benzoxazole complexes with 3-(triethoxysilyl)-propyl-isocyanate (TEPIC) as a linker. The supported catalysts are characterized by solid-state NMR spectroscopy, small-angle X-ray scattering (SAXS), nitrogen physisorption, FTIR spectroscopy, and electron microscopy analysis, which indicate that the coordination environment of the iridium center as well as the two-dimensional hexagonal pore structure of SBA-15 is maintained after the immobilization. These supported catalysts have been successfully applied to the selective transfer hydrogenation of quinoline derivatives to 1,2,3,4-tetrahydroquinolines (THQs) with formic acid in pure water. Moreover, by simply adapting the amount of formic acid used, N-formyltetrahydroquinolines (FTHQs) could be selectively synthesized from quinolines in two-step, one-pot transfer hydrogenation/N-formylation reactions with these supported catalysts. Notably, these supported catalysts showed better catalytic reactivity than their homogeneous analogs, and they can be easily reused 12 times in the transformation of quinoline to N-formyltetrahydroquinoline (FTHQ) without significant loss of activity.
Pd/C-catalyzed reductive formylation of indoles and quinolines using formic acid
Kulkarni, Aditya,Gianatassio, Ryan,Toeroek, Bela
experimental part, p. 1227 - 1232 (2011/05/14)
A two-step, one-pot domino reaction methodology was developed to synthesize a variety of N-formylindolines and N-formyltetrahydroquinolines from the corresponding indoles and quinolines. In the first step, the heterocyclic compounds are reduced to the corresponding dihydro or tetrahydro products by a Pd/C-catalyzed transfer hydrogenation using formic acid as a hydrogen donor. In the second step, nitrogen is formylated by formic acid to afford the final products in very good isolated yields. Georg Thieme Verlag Stuttgart New York.
Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
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Page/Page column 36, (2008/06/13)
The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, A, B, D, m, n, x, and y are defined as described in the specification. The invention additionally provides a pharmaceutically composition comprising the compound of formula I, together with a method of using the same to treat or prevent neurological and psychiatric disorders. The compounds are useful in therapy related to the treatment or prevention of mGluR2 receptor-mediated disorders.
