348613-08-1

Basic information

• Product Name: N,N-diethyl-2-(2-methoxyphenyl)acetamide
• Synonyms: N,N-diethyl-2-(2-methoxyphenyl)acetamide
• CAS NO: 348613-08-1
• Molecular Weight: 221.299
• Mol File: 348613-08-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-2-(2-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-(2-methoxyphenyl)acetamide(348613-08-1)
• EPA Substance Registry System: N,N-diethyl-2-(2-methoxyphenyl)acetamide(348613-08-1)

Safety Data

• Hazardous Substances Data: 348613-08-1(Hazardous Substances Data)

Upstream product

• 99-59-2 3-amino-4-methoxynitrobenzene 
• 93-25-4 2-methoxyphenylacetic acid 
• 109-89-7 diethylamine 
• 28033-63-8 2-(2-methoxyphenyl)acetyl chloride 

Downstream Products

• 1422748-06-8 2-(2-benzoyl-6-methoxyphenyl)-N,N-diethylacetamide 
• 1422748-12-6 N,N-diethyl-2-(2-methoxy-6-(4-methoxybenzoyl)phenyl)acetamide 
• 1422748-13-7 N,N-diethyl-2-(2-methoxy-6-(3-methoxybenzoyl)phenyl)acetamide 
• 1422748-14-8 C₂₁H₂₅NO₃ 
• 1422748-16-0 N,N-diethyl-2-(2-methoxy-6-(3-nitrobenzoyl)phenyl)acetamide 
• 1422748-17-1 N,N-diethyl-2-(2-(3-fluorobenzoyl)-6-methoxyphenyl)acetamide 
• 1422748-18-2 N,N-diethyl-2-(2-(4-fluorobenzoyl)-6-methoxyphenyl)acetamide 
• 1422748-19-3 2-(2-(4-chlorobenzoyl)-6-methoxyphenyl)-N,N-diethylacetamide 
• 1422748-20-6 2-(2-(2-naphthoyl)-6-methoxyphenyl)-N,N-diethylacetamide 
• 1422748-21-7 N,N-diethyl-2-(2-(hydroxy(phenyl)methyl)-6-methoxyphenyl)acetamide 
• 1422748-22-8 5-methoxy-1-phenylisochroman-3-one 
• 33567-59-8 (2-methoxy-phenyl)-acetaldehyde 

Relevant articles and documents

Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group

A general synthesis of highly substituted 2-naphthols based on a new carbanionic reaction sequence is demonstrated. The reaction exploits the dual nature of lithium bases consisting of consecutive ring opening of readily available coumarins with either LiNEt2 or LiNiPr2 into Z-cinnamamides, thus generating a directing group in situ and allowing, by conformational freedom, a lateral directed remote metalation for ring closure to give the aryl 2-naphthols in good to excellent yields. These transformations can be combined to provide a more efficient one-pot process. Mechanistic insight into the remote lateral metalation step, demonstrating the requirement of Z-cinnamamide, is described. Application of this methodology to the synthesis of highly substituted 3,3′-diaryl BINOL ligands is also reported.

A practical in situ generation of the schwartz reagent. reduction of tertiary amides to aldehydes and hydrozirconation

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method for the amide to aldehyde reduction and the regioselective hydrozirconation-iodination of alkynes and alkenes. Highlighted are chemoselective reductions of benzamides derived by directed ortho metalation (DoM) chemistry, allowing the synthesis of valuable 1,2,3-substituted benzaldehydes. The single-step, three-component process proceeds in a very short reaction time, shows excellent functional group compatibility, and uses inexpensive and long-storage stable reducing reagents.

Metaphenylenediamines in dyeing compositions for keratinic fibers

Dye compositions comprising a coupler having to the formula STR1 in which formula R1 and R2 are identical or different and represent a hydrogen atom or an alkyl radical having 1 to 2 carbon atoms and n represents a number equal to 1 or 2 and a paraphenylenediamine. This coupler is particularly suitable for use in a dyeing composition comprising paraphenylenediamines responding to the formula STR2 or the corresponding acid salts; formula in which R1, R2 and R3 are identical or different and represent a hydrogen atom, an alkyl or alkoxy radical having 1 to 2 carbon atoms, R4 and R5 are identical or different and represent a hydrogen atom, a alkyl radical, hydroxyalkyl, alkoxyalkyl in which the alkoxy group comprises 1 to 2 carbon atoms, carbamylalkyl, mesylaminoalkyl, acetylaminoalkyl, ureidoaminoalkyl, carbethoxyaminoalkyl, the alkyl groups in R4 and R5 having 1 to 3 carbon atoms, with the reservation that R1 or R3 represents hydrogen when R4 and R5 do not represent a hydrogen atom.