34875-04-2Relevant academic research and scientific papers
Rh-Catalyzed Asymmetric Hydrogenation of β-Substituted-β-thio-α,β-unsaturated Esters: Expeditious Access to Chiral Organic Sulfides
Liu, Gang,Han, Zhengyu,Dong, Xiu-Qin,Zhang, Xumu
supporting information, p. 5636 - 5639 (2018/09/12)
Rh/bifunctional bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydorgenation of both (Z)- and (E)-isomers of β-substituted-β-thio-α,β-unsaturated esters was successfully developed. This new asymmetric catalytic methodology provided highly efficient access to two enantiomers of chiral organic sulfides ethyl β-substituted-β-thio-propanoates with excellent results (up to 99% yield and >99% ee for (Z)-substrates, up to 99% yield and 98% ee for (E)-substrates, TON up to 5000), which are important intermediates in organic synthesis.
