3490-79-7Relevant academic research and scientific papers
Nosylaziridines: Activated aziridine electrophiles
Maligres, Peter E.,See, Marjorie M.,Askin, David,Reider, Paul J.
, p. 5253 - 5256 (2007/10/03)
Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.
β-Alkoxy-substituted phenethylamines: A family of compounds potentially active at the dopamine and α-adrenergic receptors
Katerinopoulos,Tagmatarchis,Zaponakis,Kefalakis,Kordatos,Spyrakis,Thermos
, p. 949 - 954 (2007/10/03)
A series of β-alkoxy-substituted phenethylamines were synthesized and tested for their affinity at the D1 and D2 dopaminergic receptors and the α1 and α2 adrenoceptors. None of the tested compounds exhibited D2 receptor af
Secondary amines and use in pharmaceutical compositions
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, (2008/06/13)
A compound of formula (I): STR1 or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula STR2 wherein R1 is hydrogen or fluorine, R2 is hydrogen, C1-6 alkyl, halogen or trifluoromethyl; or W is a phenoxymethyl or benzofuran-2-yl group; R3 is C1-12 alkyl or phenyl C1-6 alkyl; A is hydrogen or methyl, X is carboxy, --Z--CO2 H, --Z--OH, T--Z--CO2 H, --Z--NR4 R5, --T--Y--OM, --T--Y--NR4 R5, or --T--R6, in the para- or meta-position with respect to the --(CH2)n group, wherein R4 and R5 are each hydrogen or C1-6 alkyl, R6 is C1-6 alkyl, T is 0, S, --NH or --N--R7, in which R7 is C1-6 alkyl Z is C1-10 straight or branched alkylene optionally containing a carbon-carbon double bond; Y is C2-10 straight or branched alkylene, provided that the hetero atoms in --T--Y--OM and --T--Y--NR4 R5 are separated by at least two carbon atoms, M is hydrogen, C1-6 alkyl or phenyl, and n is 1 or 2, is useful for obesity or hyperglycaemia.
