194156-48-4Relevant academic research and scientific papers
Double Functionalization of Styrenes by Cu-Mediated Assisted Tandem Catalysis
Kawauchi, Daichi,Ueda, Hirofumi,Tokuyama, Hidetoshi
supporting information, p. 2056 - 2060 (2019/03/13)
The double functionalization of styrenes through Cu-mediated assisted tandem catalysis was developed. The reaction was initiated by Cu-catalyzed aziridination and the subsequent nucleophilic ring-opening, which was triggered by the addition of (NH4)2S2O8 as an oxidant of Cu-catalyst to form a variety of C–C and C–X bonds. The expansion to three contiguous catalytic cycles led to the synthesis of functionalized indolines by one-pot operation.
Synthesis of β-alkoxy-: N -protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
Saavedra-Olavarría, Jorge,Madrid-Rojas, Matías,Almodovar, Iriux,Hermosilla-Ibá?ez, Patricio,Pérez, Edwin G.
, p. 27919 - 27923 (2018/08/16)
A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.
Nosylaziridines: Activated aziridine electrophiles
Maligres, Peter E.,See, Marjorie M.,Askin, David,Reider, Paul J.
, p. 5253 - 5256 (2007/10/03)
Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.
