34911-21-2Relevant academic research and scientific papers
Analgesic and tranquilizing activity of 5,8 disubstituted 1 tetralone Mannich bases
Welch,Harbert,Sarges,Stratten,Weissman
, p. 699 - 705 (1977)
5,8-Disubstituted 1-tetralone Mannich bases represent semirigid variants of classical (i.e., chlorpromazine) neuroleptic agents. 8-Chloro-5-methoxy-2- morpholinomethyl-1-tetralone exhibits neuroleptic potency in the thiothixene range in animal models. Of greater potential interest, however, is the analgesic potency of the 8-chloro-5-methoxy-2-pyrrolidinomethyl analogue which was in the morphine range. This compound did not induce tolerance nor was its activity reversed by naloxone. Structure-activity relationships of the series are discussed.
