Journal of Medicinal Chemistry p. 699 - 705 (1977)
Update date:2022-08-29
Topics:
Welch
Harbert
Sarges
Stratten
Weissman
5,8-Disubstituted 1-tetralone Mannich bases represent semirigid variants of classical (i.e., chlorpromazine) neuroleptic agents. 8-Chloro-5-methoxy-2- morpholinomethyl-1-tetralone exhibits neuroleptic potency in the thiothixene range in animal models. Of greater potential interest, however, is the analgesic potency of the 8-chloro-5-methoxy-2-pyrrolidinomethyl analogue which was in the morphine range. This compound did not induce tolerance nor was its activity reversed by naloxone. Structure-activity relationships of the series are discussed.
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Doi:10.1016/0022-328X(84)80706-8
(1984)Doi:10.1016/j.tetlet.2003.12.091
(2004)Doi:10.1021/jo01137a003
(1952)Doi:10.1016/S0040-4020(01)97860-3
(1970)Doi:10.1016/0040-4039(95)02363-1
(1996)Doi:10.1021/ac60362a008
(1975)
