349129-65-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-N-propylbenzamide is used as a pharmaceutical compound for its potential as a ligand for the sigma-1 receptor. This interaction may contribute to the development of new drugs aimed at treating neurological and psychiatric conditions by modulating the central nervous system.
Used in Research and Development:
In the field of medicinal chemistry, 4-Fluoro-N-propylbenzamide serves as a valuable research tool. It aids scientists in understanding the mechanisms of action and potential therapeutic effects of sigma-1 receptor ligands, which can lead to the discovery and optimization of novel drug candidates for various medical applications.

Upstream product

• 107-10-8 propylamine 
• 403-43-0 4-fluorobenzoyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 39887-14-4 N-allyl-4-fluorobenzamide 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1181384-63-3 4-fluoro-N-propionyl-benzamide 

Relevant academic research and scientific papers

Cobalt-catalyzed alkene hydrogenation by reductive turnover

Earth abundant metal catalysts hold advantages in cost, environmental burden and chemoselectivity over precious metal catalysts. Differences in reactivity for a given metal center result from ligand field strength, which can promote reaction through either open- or closed-shell carbon intermediates. Herein we report a simple protocol for cobalt-catalyzed alkene reduction. Instead of using an oxidative turnover mechanism that requires stoichiometric hydride, we find a reductive turnover mechanism that requires stoichiometric proton. The reaction mechanism appears to involve coordination and hydrocobaltation of terminal alkenes.

Visible-Light-Driven Oxidation of N -Alkylamides to Imides Using Oxone/H 2 O and Catalytic KBr

Imides are prepared conveniently by visible-light-driven oxidations of various N -alkylamides under mild conditions. The majority of the reactions proceed efficiently by using Oxone as the oxidant in the presence of a catalytic amount of KBr in H 2 O/CH 2 Cl 2 under irradiation by an 8 W white LED at room temperature. Experimental studies suggest that an imine, obtained from the substrate amide via a radical process, is the key intermediate.

Lewis acid mediated fragmentation of tetrazoles towards triazoles

If Ugi-azide adducts generated from tert-butyl isocyanide, primary amines, and aromatic aldehydes are oxidized by copper(II) salts, the resulting imino tetrazoles may be easily converted into triazoles through Lewis acid catalyzed fragmentation of the tet

Copper mediated oxidation of amides to imides by Selectfluor

The combination of Selectfluor and copper(I) bromide has shown a strong oxidation ability, readily oxidizing amides into the corresponding imides in acetonitrile at room temperature in less than 1 h. This transformation under mild conditions gives good to excellent chemical yields. A possible reaction mechanism is proposed.