349148-01-2Relevant academic research and scientific papers
cis-6-phenyl-4bH,6H,11H,13H-isoindolo[1,2-c]benz[2,4]oxazepin-13-one
Lokaj, Jan,Kettmann, Viktor,Marchalin, Stefan,Sikoraiova, Jana
, p. 735 - 736 (2001)
The title compound, C22H17NO2, contains an isoindolinone moiety joined to a phenyl-substituted benzoxazepine ring. The isoindolinone moiety is essentially planar and the oxazepine ring adopts a distorted chair conformation, with the phenyl substituent equatorial. Owing to the severe puckering of the central oxazepine ring, the molecule as a whole is non-planar; the benzene ring of the benzoxazepine fragment makes an angle of 67.7 (1)° with respect to the isoindoline ring.
Intramolecular addition of a hydroxyl to a N-acyliminium system. Application to the synthesis of isoindolo[2,1-a] [3,1]benzoxazine and isoindolo[1,2-c][2,4] benzoxazepine derivatives
Pigeon, Pascal,Sikoraiova, Jana,Marchalin, Stefan,Decroix, Bernard
, p. 129 - 138 (2007/10/03)
The titled compounds were prepared by the reaction of hydroxylated lactam (3a-c) or (10) with p-toluenesulfonic acid in dichloromethane. The ratio of diastereomeric mixtures (4b/5b (2/1) or 4c/5c (2/1) or 11/12 (5/1)) is discussed.
